Sentences with phrase «gpcr structural studies»

An example of how structural studies of this type might differ from more conventional studies might clarify the discussion at this point.

The study, published by the journal Science via First Release on April 12, paves the way for determining the structures of other functional states of the ATP synthase, which has been the subject of structural studies for decades in labs across the globe.

Researchers at Umeå University show in a new, detailed structural study, published in the journal Nature Communications, how the binding of the signal - sequence triggers a number of structural changes within the SRP particle.

The pace of structural studies in this field is breathtaking, and there is still a lot unknown.»

Electrophysiology and structural studies were performed on an annexin V variant containing a mutation of glutamic acid - 95 to serine in the center of the pore region.

Structural studies suggest a route to improve the performance of rechargeable batteries.

Structural studies of chromatin so far have only given us a static view of how DNA is organized in cells.

Structural studies give insight into how a human sodium channel involved in pain perception can be selectively inhibited.

After deciphering the crystal structure of the catalytic domain of PHA synthase, in addition to other structural studies on whole enzyme and related proteins, the research team also performed experiments to elucidate the mechanisms of the enzyme reaction, validating detailed structures, enzyme engineering, and also N - terminal domain studies among others.

Related research (Pereira HJ, et al., 2012) used two different lines of evidence to explain the increase in the ratio of anteiso — to iso - branched alkenes that was observed during the transition from early to late stationary phase in M. luteus: structural studies of a key enzyme involved in fatty acid biosynthesis in M. luteus (FabH, or ß - ketoacyl - ACP synthase III) and transcriptional (whole - genome microarray) studies of M. luteus during different growth phases.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

Maoka T. Recent progress in structural studies of carotenoids in animals and plants.

These samples are useful for both structural studies and ligand binding assays.

Structural studies of apelin and its receptor as well as the characteristics and causes of membrane protein helix kinks.

The Deaconescu Laboratory focuses on structural studies by X-ray crystallography, small - angle X-ray scattering and electron microscopy of protein - protein and protein - nucleic acid complexes, particularly those involved in DNA repair and transcriptional regulation.

There are already plans for a new infrared beamline at the ALS that will increase the capacity and capabilities for infrared chemical studies and also launch infrared - based 3 - D structural studies at the ALS.

How hard are GPCR structural studies?

The team crafted the peptide using clues from structural studies of one of Gαq's known signaling partners.

Brunger also employs single - molecule fluorescence microscopy methods to complement his structural studies.

The last steps of preparing a protein sample for downstream analyses, such as activity assays or structural studies, involve ensuring that the protein is in its native, soluble form, dissolved in the buffer of choice, and at an appropriate concentration.

Yet despite the transformative impact on structural studies, it takes months to produce specifically tailored nanobodies by llama immunization.

In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure - activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest.

De Camilli's colleagues did a structural study and found that E-Syt can dimerize and harbor lipids.

Here, we present the 2.8 Å crystal structure of human CB1 in complex with AM6538, a stabilizing antagonist, synthesized and characterized for this structural study.

Because high - resolution structural studies of the human Nav1.7 channel are hindered by the molecules complexity, these researchers exploited a simpler bacterial Nav channel by fusing portions of human Nav1.7 (i.e. VSD4) onto it.

12:15 — 12:45 Marta Ferraroni (Uni Firenze) Structural studies on Ring - Cleaving Dioxygenases involved in the degradation of aromatic compounds

This resource covers Part 5 of the novel and includes character studies, close reading, thematic and structural studies, hot seating, creative writing, group work, peer assessment and DIRT activities, all with a nod to SMSC.

The exhibition presents the firm's work over the last 15 years, including 17 bold and captivating architectural sculptures alongside material and structural studies.

Phylogenetic and structural studies in the Thelebolaceae (Ascomycota).

Enable follow - up structural studies by obtaining pure samples after isolating primary proteins.

All structural studies included employed a standard VBM analysis protocol.

Not exact matches

Ronald Burt is a sociologist in the University of Chicago's Booth School of Business who for more than 30 years has studied the phenomenon of «structural holes,» i.e., gaps within organizations.

The university also ranks among the top 50 universities in the world for linguistics, computer science and information systems, civil and structural engineering, electrical and electronic engineering, mechanical engineering, agriculture and forestry, psychology, chemistry, environmental studies, materials science, physics and astronomy, and other fields.

However, the Organization for Economic Co-operation and Development studied structural separation (links to PDF) across various industries several years ago and didn't find that to be the case:

The CRTC studied the idea of structural separation way back in the early nineties before ultimately rejecting it in 1994, opting to go with a less - stringent wholesale regime instead.

Indeed, though an 2014 academic study of bridge failures found roughly 120 bridges collapse or partially collapse every year, most do so because of floods, fires and collisions rather than structural decline.

«We the public should feel safe,» said Wesley Cook, a structural engineer at the New Mexico Institute of Mining and Technology who authored the 2014 bridge failure study.

June 2008 (264 kb PDF file): IMF research summaries on Latin America's external linkages (by Shaun Roache) and on reaping the benefits of structural reforms (by Stephen Tokarick); regional study on the Eastern Caribbean Currency Union (by Paul Cashin and Evridiki Tsounta); listing of visiting scholars at the IMF during March — April 2008; listing of contents of Vol.

As shown in previous studies (www.3dpolicy.ca), the federal government has a relatively small structural deficit.

But according to a recent C.D. Howe study, the federal government could run a permanent structural deficit of 1 % of GDP ($ 20 billion) and still maintain a stable debt ratio of 25 %, which happens to be the Conservative government's target for 2022.

Despite this highly detailed panel of data, the statistical relationships are little studied, and the blockchain economy frequently experiences structural breaks.

Rather than simply emphasizing levels of institutional differentiation, as many modernization studies have, proponents of structural contingency have stressed the importance of resource flows, overlapping memberships, mutual and competitive interests, and organizational interactions.

The structural emphasis in these studies might be described as an interest in institutional arrangements.

Drawing on the large numbers of studies undertaken by people in the aid world and by independent researchers (few of these studies are cited in Lancaster's volume), he points out that the structural reforms have largely failed and the situation continues to deteriorate.

It may be that the preacher will find the apparent points of some structural value later on in preparation but only after his study has led him to the point the author sought to make.

The study found that 72 percent of African Americans in predominantly black churches believe that the reasons for racial inequality are structural, rather than an individual's lack of motivation.

In contrast, the social - science approach seeks structural and cultural contexts for personages in the past by studying the actual behavior of contemporary people with similar social structures, values and human types.

Terry J. Prewitt's The Elusive Covenant: A Structural Semiotic Reading of Genesis (Advances in Semiotics Series, Bloomington: Indiana University Press, 1990, 160 pp., $ 20.00) integrates the study of literary form, sign theory and kinship structures to demonstrate unifying structures in the narrative.

The personnel of FOODPRO are pleased to offer a complete range of consulting engineering services from studies (planning, feasibility, site selection, etc.) through construction and equipment installation management including all the engineering disciplines (industrial refrigeration, electrical, structural, etc.) necessary for complete plans and specifications.

Many ecological studies support the key role of structural diversity (sometimes referred to technically as floristic heterogeneity) in increased biodiversity — of many types in many ecosystems well beyond the realm of coffee growing.