The structure of YqeH: An AtNOS1 / AtNOA1 ortholog that couples
gtp hydrolysis to molecular recognition
Polarization of diploid daughter cells directed by spatial cues and
GTP hydrolysis of Cdc42 in budding yeast.
Using lipid nanotubes as substrates to directly measure geometric intermediates of the fission pathway, we found that
GTP hydrolysis limits dynamin polymerization into short, metastable collars that are optimal for fission.
«Our study shows how EB proteins can either facilitate microtubule assembly by binding to sub-units of the microtubule, essentially holding them together, or else cause a microtubule to disassemble by promoting
GTP hydrolysis that destabilizes the microtubule lattice,» says Eva Nogales, a biophysicist with Berkeley Lab's Life Sciences Division who led this research.
Not exact matches
The dynamic instability that makes it possible for microtubules to transition from a rigid polymerized or «assembled» nucleotide state to a flexible depolymerized or «disassembled» nucleotide state is driven by guanosine triphosphate (
GTP)
hydrolysis in the microtubule lattice.