Sentences with phrase «gene alterations linked»
Gene Alterations Linked to Poor Outcomes in A Pediatric Cancer A survey of the neuroblastoma cancer genome revealed alterations in two genes, ARID1A and ARID1B, associated with a poor prognosis.
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About 10 to 15 percent of people with autism have a disorder linked to a known single - gene mutation, such as fragile X syndrome, or chromosomal alterations.
Learning more about how synapses change their connections could help scientists better understand neurodevelopmental disorders such as autism, since many of the genetic alterations linked to autism are found in genes that code for synaptic proteins.
An alteration in the neuregulin - 1 gene — a single change in one letter of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.
Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.
None of the modified genes has a direct link to cancer, however, making it unclear whether these chemical alterations increase the risk of developing the disease.
In 1989, Vogelstein's identification of p53 gene mutations in colon cancer began a tide of research linking alterations in the gene to other cancers.
Forms of variation include single DNA base pair alterations, duplications or deletions of genes or sets of genes, and translocations, a chromosomal rearrangement in which a segment of genetic material from one chromosome becomes heritably linked to another chromosome.
In addition, the mutations in ARID1A provide an important new link between genetic and epigenetic (alterations to the environment of genes) mechanisms in human cancer.
Because the pathophysiology of cancer is linked to alteration of cellular gene expression, the bioinformatics toolbox promises to offer countless molecular insights into mechanisms, diagnostics, and new medical interventions for cancer.