Sentences with phrase «gene rearrangement by»

They then looked for DNA breaks associated with receptor gene rearrangement by using a version of the polymerase chain reaction that amplifies broken DNA.

Not exact matches

To that end, the US National Center for Biotechnology Information in Bethesda is developing a database, ClinVar, to integrate clinical and genetic data; others, such as DECIPHER, run by the Sanger Institute, handle genetic data such as chromosome rearrangements that can disrupt genes.

About 4 percent of NSCLCs are driven by genetic aberrations called ALK gene rearrangements, according to Farace.

Dorothy Romanus, lead author of the study, states «this analysis supports the value of multiplexed testing for EGFR and ALK gene rearrangements followed by molecularly - guided therapy in decisions surrounding coverage of related testing and targeted therapy.

The growth of long facial feathers, creating the appearance of muffs and beards on chickens, is caused by a chromosomal rearrangement affecting a gene involved in feather development, report Xiaoxiang Hu of the China Agricultural University in Beijing and colleagues, in a new study published on June 2 in PLOS Genetics.

Tipped off by a suspicious chromosomal rearrangement, researchers have identified a gene they believe causes Tourette syndrome when mutated.

Pairwise alignments were calculated using Shuffle - LAGAN (window size, 400 bp; step size 40 bp; translated anchoring), a glocal alignment algorithm that is able to calculate optimal alignments by using both local alignments and global maps of sequence rearrangements (e.g. duplications of the fiber gene in adenovirus genomes with 2 fibers)[57].

She found, for example, that by using a technique called the polymerase chain reaction to amplify genes, she could detect mutations or rearrangements in cancer - specific genes in irradiated tissue that had turned cancerous.

This subgroup of AML is trickier than APL, where the product of the gene created by the chromosomal rearrangement directly blocks the cancer cells from becoming their normal type.

Studies on horizontal gene transfer and enzymemediated DNA rearrangements lead him to postulate a theory of molecular evolution according to which nature cares actively for the promotion of biological evolution by using products of specific evolution genes as well as several intrinsic non-genetic elements.

In 6 cases, Ig / TCR gene rearrangement test did not detect BM involvement, which was presented by microscopy.

In 5 % (6/119) of B cell neoplasias, the BM involvements were detected by microscopic evaluation, but Ig gene rearrangements were negative.

We have been searching for a mechanism that can explain the genetic cause of majority of BWS and that can provide better understanding of intragenic mutation of p57KIP2 and disruption of KvLQT1 gene by balanced germline chromosomal rearrangements.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as DantBy analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantby a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.