The Computational Biology &
Gene Regulation group aims at developing cutting - edge bioinformatics tools with immediate application to real - life biological problems.
Not exact matches
Specifically, Toni Gabaldón's
group at the Centre for Genomic
Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify
genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.
A new function now described for the protein dDsk2 by the team headed by Ferran Azorín,
group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the
regulation of
gene expression.
The research that led to these findings is part of a larger effort to better understand
gene regulation and expression, carried out by the GTEx Consortium, a National Institutes of Health - funded
group that includes researchers from around 80 institutions founded in 2010.
The
groups of Santiago Lamas, Lisardo Bósca, and Juan Miguel Redondo explore various aspects of
gene regulation and pathophysiological processes in the vascular wall.
The 28
groups that will eventually make up the CRG will be organised around five main programmes —
Gene Regulation, Development and Cell Biology, Cell Differentiation and Cancer,
Genes and Diseases, and Bioinformatics and Genomics — each of which will be headed by a senior scientist leading his or her own
group.
The team discovered that the
genes responsible for the
regulation of NRL became more refined in the placental mammals as the modern retina evolved and were lost in several non-mammalian
groups.
«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple,
group interactions that could play a key role in the
regulation of
genes,» explains Nicodemi.
In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research
group continued to study the
regulation of interferon
genes and discovered the interferon - regulatory - factor family of transcription factors.
It is an important factor for the correct
regulation of
gene expression within all these
groups of organisms.
Using drug repurposing, Yoshimura's
group not only identified circadian rhythm changing drugs, but also succeeded in identifying
genes that are involved in the
regulation of the circadian clock.
Several functions vary among the members of this
group of bacteria, such as metabolism of nitrogen, respiration, cell wall and capsule, stress response, secondary metabolite biosynthesis,
regulation and cell signaling; this variation in
gene functions could help us understand the ability of colonization and adaptability of these rhizosphere - colonizing bacteria.
The main research focus of the single molecule
group is the study of molecular motors, the role of force in regulating biological systems, and the molecular mechanisms of
gene expression
regulation.
In a paper published in Nature Genetics, an interdisciplinary research team of scientists from the Centre for Genomic
Regulation (CRG)-- including a Centro Nacional de Análisis Genómico (CNAG - CRG)
group — in Barcelona, Spain, shows that the three - dimensional organisation of the genome plays a key role in
gene expression and consequently in determining cell fate.
The Kind
group studies the
regulation of
gene expression in single cells by developing and using novel microscopy and genomics based techniques.
His
group work on understanding the
regulation of
gene expression, especially at the single - cell level where he has pioneered analytical approaches.
The
groups plan to further characterize
gene activity in tissues by analyzing several molecular phenotypes, or properties of cells - such as which
genes are turned on and off, the various ways
genes are regulated and the proteins that cells produce based on such
regulation.
Professor Dockrell and her
group are investigating mechanisms that regulate the production of immune - related proteins, starting from
gene regulation (epigenetics),
gene expression (transcriptomics), cell phenotypes (flow cytometry) and finally protein release.
In 2006, she became a Research Fellow at the Hormone Action and Oncogenesis
group at the LRBGE and extended her work on GR biology and GR - target
genes regulation in response to the ultradian secretion of glucocorticoids occurring naturally in mammalian systems.