Sentences with phrase «gene variant linked»

ASHG 2015: Common Gene Variant Linked to Chromosome Errors and Early Pregnancy Loss ASHG Press Release — October 8, 2015

«Gene variant linked to schizophrenia, bipolar disorder, alcoholism.»

The gene variant linked to graying is found only in people with European ancestry, and it has previously been associated with light hair colors.

Researchers at Karolinska Institutet, and the Sahlgrenska Academy at Gothenburg University in Sweden have identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder.

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

Last week, Nature reported that Pier Valerio Reinotti, an appeal court judge in Trieste, Italy, cut Bayout's sentence by a year after finding out he has gene variants linked to aggression.

After analyzing human DNA from several populations around the world and examining primate genomes dating back to the shared ancestor of both humans and chimpanzees, researchers reached a striking conclusion that several gene variants linked to schizophrenia were actually positively selected and remained largely unchanged over time, suggesting that there was some advantage to having them.

«Identifying these gene variants linked to both type 2 diabetes and CHD risk in principle opens up opportunities to lower the risk of both outcomes with a single drug,» said study co-senior author Danish Saleheen, PhD, an assistant professor of Biostatistics and Epidemiology.

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

In 2008, researchers linked variants in the gene to the strong, frightful reaction some people have to horror movies.

Three of the darker - skin gene variants appear to have evolved from variants linked with less pigment.

Their landmark findings will open the door to identify gene variants controlling skin microbiota and to define their link to various diseases such as skin inflammatory disorders.

To link, at a molecular level, a gene variant with biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present study, is therefore something of a breakthrough.

MUSICAL ability is linked to gene variants that help control social bonding.

They discovered that several genetic variants in the hunter - gatherers were linked to a gene associated with physical performance, which they hypothesise could be part of the physiological adaptation to cold.

Other gene variants — like mutations in FTO or the gene for leptin, an energy - balancing hormone — had been linked to overeating or fat cell type.

The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin - 1 gene — which reduces production of the receptor — is strongly linked to increased asthma risk.

New genome - sequencing research suggests white European people with two copies of variant forms of MC1R, a gene linked to pale skin and red hair, have faces that appear up to two years older than those who are the same age but don't have both copies.

These discoveries build upon previous findings about genes linked to Alzheimer's, such as the APOE - 4 gene, which is a powerful marker for late - onset Alzheimer's disease; about 40 percent of those diagnosed have this DNA variant.

A variant of this gene has been linked to aches in response to statins.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

The variant is in a gene called HMGA2, which has previously been linked with people's height.

A study of people from an isolated village in the Netherlands reveals a link between rare variants in the gene NKPD1 and depressive symptoms.

Interestingly, a variant of the WNT10A gene associated with lower levels of its protein's expression has been linked to a greater likelihood of male pattern baldness, according to a recent genome - wide association study.

Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't find evidence that Neandertal gene variants contribute to obesity.

This year, however, researchers linked variants of more than 50 genes to increased risk for a dozen diseases.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

The scientists have also linked the gene variant to a mechanism that explains the elevated risk and offers clues about the broader anti-viral immune response.

Genetic screening later revealed that 24 percent of centenarians from Ashkenazi Jewish populations carry a variant in the CETP gene — an enzyme important for cholesterol metabolism — that reduces the level of the protein CETP in the blood and is linked to a lower prevalence of hypertension, cardiovascular disease and memory loss.

A variant in the gene for this receptor previously had been linked to asthma in genetic studies, but the potential role of the receptor, called CDHR3, in asthma was unknown.

«Surprisingly, when we looked for shared gene variants that might help explain part of the link between migraine and heart disease, we found no shared gene variations between migraine with aura and heart disease,» said study author Aarno Palotie, MD, of the Broad Institute of MIT and Harvard.

Stice's group also genotyped these young women to determine whether or not they possessed variant alleles of two genes (DRD2 Taq1A A1 and DRD4 - 7 +) that have been linked with lower dopamine activity and, in some studies, obesity.

«Men with the gene variant that is linked to aggression may be less able to inhibit their emotional responses»

PEOPLE with a gene variant known to be linked to aggression may have been born with key brain differences that could make them more likely to snap under pressure.

With their analyses of the genome data, the scientists were also able to identify eight specific gene variants that are strongly linked to altered risk for both diseases.

Additional studies showed that other CYP gene variants are linked to the rapid metabolism of clopidogrel and that patients with those variants had a higher risk of bleeding.

There's also a genetic component: The condition, which can occur at any age, often runs in families and specific gene variants have been linked to it.

These scientists studied whether a gene variant in the FTO gene, which regulates the appetite and thereby increases the individual's BMI, is also linked to a series of cardiovascular diseases and metabolism.

Also, a number of large - scale genomics studies have linked variants of the CPEB4 gene with the impairment of fat metabolism.

The Neurogenomiks research group, linked to the Achucarro Basque Centre for Neuroscience (EHUgroup) and the University of the Basque Country (UPV / EHU), has just had a research article published in the scientific publication Journal of Immunology; it details how they have managed to show that the gene known as ANKRD55 produces 3 different transcripts of the messenger RNA, and that the genetic variant associated with MS greatly increases the production of these transcripts.

To probe the link between gene and virus, neuroscientist HowardFederoff, of the University of Rochester School of Medicine, and his colleagues created mouse - cell cultures that expressed either theAPOE - e4 gene or another variant (APOE - e2 or APOE - e3), then infected the cells with herpes.

About 30 years ago, scientists found a link between MS and certain variants in the major histocompatibility complex (MHC), a cluster of genes that help the immune system distinguish between the body's own proteins and those of microbial invaders.

But specific gene variants are also linked to greater risks of developing many of these diseases.

They then used the model to predict how autism - linked variants in the NHE9 gene would affect the protein's shape and function.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

After looking at 9 million genetic variants in those who were asparagus anosmic, they linked this deficiency to 871 individual sequence variations they discovered in chromosome 1, on genes associated with our sense of smell.

This finding underscores the role of genetics in the pathogenesis of this devastating illness, and represents a critical milestone on the way to identifying a gene and its disease - linked variants.

At the time of the initial Fetalis results assessment of Case 7 in May 2015, there had been no published reports directly linking ZIC1 gene variants to a recognizable pathological phenotype and thus, in accordance with our testing and reporting guidelines, the maternally inherited ZIC1 gene variant was reported as a VOUS.

In 2007, researchers found that variants of the FTO gene were linked to obesity, but despite intense scrutiny, no direct link was found.

Nearly all of the affected children had the HLA - QB * 06:02 gene variant already linked with narcolepsy.