Sentences with phrase «gene deletion mutants»

Gene deletion mutants of the same pathway or with similar fitness alterations in steady conditions can largely differ in their response to dynamic conditions.

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A series of genetic analyses confirmed that the DNA target sequence had been altered in the transgenic plants, with either DNA insertions or deletions in both copies of the DFR - B gene (so - called bi-allellic mutants).

Primers 8134 and 8135 efficiently amplify full length fragment in wild type animals (WT) while mutant animals show homozygous deletion in W01A8.1 gene.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

DNA sequencing of three quadruple - mutant colonies further confirmed that small deletions were present in all eight alleles of four genes (Figure 2F).