Gene drives designed to wipe out invasive species might be effective, but they certainly would not be «safe» from the target species» point of view.
A self - sustaining method would require the use of
a gene drive designed to persist in the environment and spread within the target population, but with some risk of spreading into a non-targeted area where that same species may be desired.
Not exact matches
Researchers have
designed ways to keep
gene drives confined in the lab, but no such safety nets exist for
gene drives released into the wild.
If they can nimbly edit any
gene in any organism, scientists ought to be able to
design a
gene drive for that species as well.
The whole point of a
gene drive is to disperse in the wild, but government regulations are
designed to keep genetic engineering out of wild organisms, says Zach Adelman, a molecular biologist at Virginia Tech in Blacksburg.
Esvelt plans to develop CRISPR
gene drives in nematode worms — a fast - reproducing model organism — that are
designed to spread a genetic modification in a local setting and then fizzle out, a concept that other scientists are pursuing.
These genies aren't magical; they are research tools known as
gene drives — clever bits of engineered DNA
designed to propel themselves into the DNA of a pesky or troubled organism.
«We've
designed a
gene drive system that dramatically biases inheritance in these flies and can spread through their populations,» said Buchman.
«The problem is cancer cells are so diverse that even though the drugs,
designed to target single cancer
driving genes, often initially are effective, they eventually stop working and patients succumb to the disease,» Peter said.
MIT's Kevin Esvelt urged caution with «global»
gene drives and described his
design of a more nuanced method he calls «daisy
drive.»
The first group, led by Valentino Gantz and Ethan Bier at the University of California — San Diego, and Anthony James at the University of California — Irvine, engineered a
gene drive carrying a pair of
genes designed to kill the malaria parasite inside the mosquito.
Improving human health by enabling safer, more effective cell and
gene medicines through proprietary genomics, bioinformatics and intelligent data
driven design
Gene drives are not without risks, and speakers were keen to advise caution about identifying dangers and
designing mitigation strategies.