IMPRINTOME STOP SIGNS:
Gene expression patterns for 42 imprinted genes (y axis) vary across diverse tissues (x axis), with redder boxes denoting stronger skewing towards just one allele.
«Gene analysis adds layers to understanding how our livers function: Tracking
gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.»
This work shows the power of using the tools of computational genomics to analyze
gene expression patterns for the purpose of elucidating the evolution of behavior.
Not exact matches
They used a computer to trawl through 2,100 of the samples and look
for patterns of
gene expression.
The trick is to run the tape of evolution over again: to intervene in the development of a chicken embryo,
for instance, to reverse evolution, rolling back the clock to manifest earlier
patterns of
gene expression.
«We used the Allen Human Brain Atlas data to quantify how consistent the
patterns of
expression for various
genes are across human brains, and to determine the importance of the most consistent and reproducible
genes for brain function.»
Although a bad outcome was possible without the
gene expression pattern, patients with the genetic signature were found to survive
for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.
Then they explored what happened to this
pattern of
gene expression when beta blocker treatment was implemented, and what they found not only surprised them, but could have important ramifications
for future treatments of heart disease.
Researchers have videotaped cultures in which embryos develop but found no visual
pattern that hints at which cells are about to sprout, and staining
for certain
patterns of
gene expression has been inconclusive.
For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation
patterns have distinct
gene expressions patterns.
In collaboration with Prof. Ido Amit of Weizmann's Immunology Department, they analyzed the genomes of 1,500 individual liver cells, establishing
patterns of
expression for about 20,000
genes in each cell.
MEGENA (
for Multiscale Embedded
Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheime
Gene Co-
expression Network Analysis) projects
gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheime
gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization
patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.
Rather than listing specific
genes that manifest themselves differently, or are differentially expressed, between queens and workers, the team looked
for genes with similar
expression patterns across samples that may be involved in maintaining the structural, behavioural and functional differences observed between queens and workers.
«We're showing
for the first time that Müller glia in the adult mouse can give rise to new neurons after injury, and these neurons have the
gene expression pattern, the morphology, the electrophysiology, and the epigenetic program to look like interneurons instead of glia,» Reh said.
The
pattern of
gene expression is strikingly similar to that
for individual olfactory receptor
genes, Liberles says.
Now, researchers at the Institute
for Comprehensive Medical Science, Fujita Health University, and ATR Computational Neuroscience Laboratories in Japan have succeeded in predicting states of mood - change - like behavior by studying the
gene expression patterns in the brain in a bipolar disorder mouse model.
I found that negative selection against new mutations and positive selection
for new mutations shape broad
patterns of genomic variation and that much of the genomic variation that actually affects
gene expression is under negative selection.
Gene expression patterns in normal adult or the developing retina have been reported
for mouse [18 — 23], aged and normal adult human [24 — 26], canine [27], and rabbit [28].
Many leukemias exhibit mixed - lineage
patterns of
gene expression,
for example of both macrophage and lymphocyte
genes.
The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled
for histone modification
patterns, DNA accessibility, DNA methylation, and
gene expression.
One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types
for histone modification
patterns, DNA accessibility, DNA methylation, and
gene expression.
The same can be said
for patterns of
gene expression changes in the same brain region
for different age frames.
Using genechip technology, a powerful tool
for analyzing the
expression patterns of thousands of
genes at a time, researchers have identified a number of
genes that are specifically regulated by the...
This resource will be valuable
for researchers studying
gene expression patterns in coral reproductive cycles and evolution of the genus Acropora.
ARNIE is an online database that integrates the extracellular protein interaction network generated in our lab using AVEXIS technology with spatiotemporal
expression patterns for all
genes in the network.
Deeper analyses, revealed that the RNA
expression pattern of a rare variant of the NCAN
gene was highly correlated with that of the previously suggested susceptibility
genes for developmental dyslexia.
«The authors went on to study the resulting blastocysts
for aneuploidy (frequency of abnormal chromosomes), and
pattern of
gene expression (which
genes are active and at what level).
In multicellular organisms, functional duplicate copies of a
gene can exist in a genome, but if their
expression patterns do not overlap, their products are unable to compensate
for each other if either
gene is mutated.
Specifically, use of post-mortem material is crucial
for studying the
patterns of normal
gene expression underlying tissue specificity within individuals, as sampling such tissues from living individuals would be impossible.
Each subtype was classified by
gene expression clustering, and showed specific
patterns of genetic alterations, particularly
for four
genes: platelet - derived growth factor receptor alpha (PDGFRA), isocitrate dehydrogenase 1 (IDH1), epidermal growfth factor receptor (EGFR), and neurofibromin 1 (NF1).
A reliability score is set manually
for all
genes and indicates the level of reliability of the analyzed protein
expression pattern based on available protein / RNA /
gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.
Using novel
gene - array technology to measure the extent of
gene expression in thousands of
genes simultaneously, this study shows that as humans diverged from their ape ancestors in the last five million years,
genes for transcription factors — which control the
expression of other
genes — were four times as likely to have changed their own
expression patterns as the
genes they regulate.
Click «
Expression Details» to view all expression annotations and details for this locus, including a visualization of genes that share a similar expressio
Expression Details» to view all
expression annotations and details for this locus, including a visualization of genes that share a similar expressio
expression annotations and details
for this locus, including a visualization of
genes that share a similar
expressionexpression pattern.
Identifying
gene expression patterns in relation to the compound could facilitate the selection of the most appropriate patient cohorts
for clinical development.
A reliability score is set
for all
genes and indicates the level of reliability of the analyzed protein
expression pattern based on available protein / RNA /
gene characterization data.
«It's been a puzzle that lots of leukemias exhibit mixed lineage
patterns of
gene expression -
for example of both macrophage and lymphocyte
genes,» he said.
The only clue indicating that differences in
gene expression level are not the reason
for the observed correlation between the recombination rate and the size of introns is that we do not see a comparable
pattern when examining the size of exons, the number of exons per
gene, and the overall size of proteins.
It has been demonstrated that the composition of the medium used
for embryo culture has a profound effect on the methylation
pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted
genes, other epigenetic alterations may intensely modify
gene expression.
Now researchers at the Salk Institute
for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way
for limb regeneration by unlocking
gene expression patterns last seen during embryonic development.
After clicking on any of the panels,
for example on the top left panel marked with a red asterisk, the
expression profiles of the individual
genes that follow the corresponding
pattern as well as their names appear in a new window (as shown in B).
Besides information gathered to answer specific experimental questions, as determined by the interests of individual partners [35]--[41], the collective data offered the opportunity to search
for coordinated
gene expression patterns in a systematic exploration of the mouse ES transcriptome under a battery of different experimental settings, thus minimizing possible site - specific artifacts.
The FunGenES database provides such a template with a number of tools including Animation of KEGG Pathways,
Expression Waves, Time Series, Specific Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene name
Expression Waves, Time Series, Specific
Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene names and
Gene Classes, such as ESTs and transcription factors, and searches
for the
expression pattern of any gene or transcript during ES cell differentiation using standard gene name
expression pattern of any
gene or transcript during ES cell differentiation using standard gene names and
gene or transcript during ES cell differentiation using standard
gene names and
gene names and IDs.
Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled
genes in groups according to their time of
expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
expression during successive days of ES cell differentiation; we have included
expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
expression profiles of specific
gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «
Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
Expression Waves» and juxtaposed to
genes with opposite or complementary
expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
expression patterns; we have designed search engines to display the
expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
expression profile of any transcript during ES cell differentiation;
gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic
expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations
for individual
genes or
gene clusters of interest and links to microarray and genomic resources.
CT values
for cyclophilin were somewhat more variable in cells isolated by flow cytometry and frozen prior to analysis, compared to freshly isolated and unmanipulated cells, but the gradients in
patterns of
gene expression were similar
for cells isolated by the two techniques (Figure 3a — d).
More recently, it has been suggested that the contrasting attributes of
gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation
for maintaining distinct
expression patterns in the
gene sets [29].
A direct positive feedback loop, in which the intracellular domain of activated Notch receptors binds to an enhancer in the second intron of the Notch1
gene to enhance its
expression, is critical
for intestinal stem cell self ‐ renewal and niche
patterning.
Moreover, they have shown that, through differential
patterns of DNA methylation of the promoter region and thereby differential
expression of the estrogen receptor alpha
gene in the medial preoptic area (MPOA) of the brain, this individual variation of early experience influences adult reproductive behaviour, suggesting a mechanism
for intergenerational transmission of the
pattern of maternal care [137, 138].