Sentences with phrase «gene inactivation by»

Not exact matches

A quirk of the physiology of C. elegans means that such gene inactivation can occur simply if the RNAi molecule is eaten by the worm.

Another is involved in X chromosome inactivation, which ensures that females don't get a double dose of proteins made by genes housed on their pair of X chromosomes.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

Inactivation of this gene in zebrafish induced retinal photoreceptor defects that were rescued by human NEK2mRNA.

Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90 % of X-linked genes into those with functional or nonfunctional Y homologs.

Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer.

Finally, the functional inactivation of our target gene by one identified pharmaceutical agent will be tested in DM1 mouse model in order to monitor its ability to impact in vivo on DM1 molecular and physiological features.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

CELPHEDIA with the partners of PHENOMIN (ICS, TAAM, CIPHE), the National Infrastructure for Mouse Phenogenomics, is committed in international consortia, such as IMPC «International Mouse Phenotyping Consortium» whose goal is to create the functional encyclopedia of the mouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functions.

Wilms» tumor is a childhood kidney cancer caused by the loss or inactivation of a tumor suppressor gene called QT1 on chromosome 11.

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism - linked gene DJ - 1

Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1 - 4 suppresses much of the hypersensitivity of tof1 ∆ strains towards this agent.

We have generated new genetic tools for the analysis of in vivo mast cell functions that allow for cell type - specific inactivation («knock out «-RRB- of target genes selectively in mast cells by Cre loxP - mediated recombination.

Mutation in a tumor suppressor gene acts in the opposite way, causing cancer in a recessive fashion by inactivation of the tumor suppressor protein.