Not exact matches
The sequences provide researchers access to 96 percent of all peanut
genes and provide the DNA
map needed to more quickly identify and genetically tag
genes that confer desirable traits,
such as drought - and disease - resistance.
Genetic tools still under construction,
such as a haplotype
map that will be used to discern genetic variation behind common diseases, could further accelerate the search for disease
genes.
And the shared
map implies that
genes for important characteristics,
such as disease resistance, photoperiodism, drought tolerance, storage proteins and the like, can be plucked direct from one genome and applied in another.
Such vectors have become critical tools for delivering
genes to treat disease or to label neurons and their connective fibers with fluorescent colors to
map out their locations.
The vectors are customizable and could potentially be used as part of a
gene therapy to treat neurodegenerative disorders that affect the entire central nervous system,
such as Huntington's disease, or to help
map or modulate neuronal circuits and understand how they change during disease.
«For our new systemic viral vectors — AAV PHP.S and AAV PHP.eB — there are many potential uses, from
mapping circuits in the periphery and fast screening of
gene regulatory elements to genome editing with powerful tools
such as CRISPR - Cas9,» says Gradinaru.
It is only the handful of
genes that differ,
such as those defining blood group, which are useful for making
maps.
The three stages of CD8 + T cell development are well known, but the current study identifies a detailed
map of the regulatory circuitry,
such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving
genes to transcribe proteins to carry out biological processes.
Positional cloning is a genetic
mapping technique used to pinpoint the location of specific traits of interest,
such as disease - causing
genes or mutations, within the genome.
This approach has contributed to the successful
mapping of
genes involved in numerous human diseases
such as Huntington's disease and cystic fibrosis, an important first step in understanding these conditions.
That
map contains several so - called islands that are unique to A. borkumensis,
such as a set of
genes that allow the organism to break down the alkanes in oil and use them as food.
That genetic
map led to key insights,
such as the link between glioblastoma, the deadliest type of brain tumor, and a
gene called BEX1.
With
such a powerful dataset and toolkit, we anticipate testing the predictions of biodiversity hotspots from stochastic modelling [28]--[31], as well as
mapping functional
gene ecology and activities throughout the world's oceans.
Utilizing genetic approaches
such as «fine
mapping» and «genome editing,» the researchers narrowed the region of the chromosome and targeted each
gene to responsible for affecting the behavioral response to the drug.
Similarly, Bernaudin et al. [43] found increased expression of 18
genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible
genes such as
MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target
genes including VEGF and GLUT - 1,
genes implicated in apoptosis, signal transduction molecules, and transcription factors.