Sentences with phrase «gene sequencing project»

Not exact matches

With the successful completion of genome - sequencing projects, science's knowledge of genes and proteins has increased exponentially.

Erwin compares the endeavor to the Human Genome Project, in which scientists mapped the sequence of our genes.

Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.

A Canadian project called FORGE (finding of rare disease genes) aims to sequence children and families with 200 different disorders this year.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

The expansive, sun - streaked laboratory sits above the university's renowned gene - sequencing center, which proved a major player in powering the Human Genome Project.

The goal of the human genome project was to use DNA sequencing to reveal all three billion DNA letters in our chromosomes and find all our genes.

Pryer's team began a crowdfunding project with the help of the online site Experiment.com, hoping to gain $ 15,000 to sequence the fern's genes.

Results from the Sequencing the Legends project are still being processed but indicate that the Bos taurus genes lurking in the Brahman genome may have been selected for important production traits associated with fertility, growth and temperament.

For one such project, the team developed a new software tool called GppFst that allows researchers to differentiate genetic drift — a neutral process whereby genes and gene sequences naturally change due to random mating within a population — from genetic variations that are indicative of evolutionary changes caused by natural selection.

As large - scale genome sequencing projects, such as the Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced genes.

«When I started this project two - and - a-half years ago, we might have had a maximum of 80 sequenced genes for this animal,» says Jennings.

By characterising the DNA sequence of these individuals, the project gained insight into the contribution of rare variants to a broad range of disease scenarios, and discovered new genetic variants and genes underpinning disease risk.

Large - scale gene - sequencing projects are revealing hundreds of autism - associated genes.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

Ruiz - Trillo and his team sequenced the Capsaspora genome in an earlier project and discovered that the amoeba contained many genes that, in animals, are related to multicellular functions.

According to Richard Durbin, who leads the project's informatics team, computer techniques seem to find most of the genes sequenced so far but frequently missed some pieces of them, particularly the short coding regions that occur at the beginning of many nematode genes.

About 70 per cent of the genes identifed so far in the nematode sequencing project bear little or no resemblance to any genes identified previously.

«Today, rapidly falling costs means that high throughput sequencing projects are revealing the entire gene sequences of ever more species, but the biological functions of most of these genes remain unknown,» said Dr. Olivier Lichtarge, professor of molecular and human genetics and director of the Computational and Integrative Biomedical Research Center at Baylor and senior author of the report.

In 1991 he invented a quick way to find human genes, using expressed sequence tags, after the senior scientists at the Human Genome Project had said it wouldn't work.

The research is part of the International Cancer Genome Consortium (ICGC)-- a global project using the latest gene - sequencing technology to reveal the genetic changes driving the disease.

The newest study from the Autism Speaks MSSNG project — the world's largest autism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of autism.

The third project will fully sequence the protein - coding regions of 1000 genes (5 % of the total) in about 1000 genomes.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

For instance, the Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communities.

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. 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(1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. 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The goals of the project are as follows: (1) to shotgun sequence the C. murisgenome to 8X coverage; (2) to sequence 20,000 clones from a C. muris cDNA library to provide gene prediction training and verification data; and (3) to manually annotate the C. muris genome sequence in comparison with the genome sequence data for C. parvum and C. hominis.

The Cancer Genome Project at the Wellcome Trust Sanger Institute is part of an international project using DNA sequencing to identify mutations in genes critical to the development of human cProject at the Wellcome Trust Sanger Institute is part of an international project using DNA sequencing to identify mutations in genes critical to the development of human cproject using DNA sequencing to identify mutations in genes critical to the development of human cancers.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

All gene sequencing that is done within the project will be performed at SciLifeLab and Anders Andersson's group will be responsible for the bioinformatics within the project.

Within RD - Connect's sister project Neuromics, Hanns was the disease coordinator for the congenital myasthenic syndromes, and in this and several other exome sequencing projects was responsible for gene discovery and work on disease modifying factors influencing severity of phenotype.

The SIGMA project aims to develop novel biomedical approaches to treat this devastating disease by applying powerful sequencing technologies to discover the genes and key pathways underlying common varieties of cancer.

Researchers with the Human Genome Project and various commercial ventures are racing to sequence the genomes of organisms in an effort to catalog all their genes.

In 1990, scientists set out to identify and sequence these genes in what has famously become known as the Human Genome Project.

If the model organism genome projects are to be maximally useful in assigning functions to human DNA sequences, they will need to utilize the powerful tools for determining gene function that are available to them so that not only the sequences of the genes, but also their biological functions, are determined.

The National Institute on Aging (NIA) and the National Human Genome Research Institute (NHGRI) were asked to develop and execute a large scale sequencing project to identify AD risk and protective gene variants.

More recently, in a joint initiative with the BBMRI - LPC project (Biobanking and Biomolecular Resources Research Infrastructure — Large Prospective Cohorts) and the Wellcome Trust Sanger Institute, the CNAG - CRG launched a call to promote the use of sequencing technologies for the identification of novel causative variants and genes and to molecularly diagnose rare disease patients.

A shotgun genome sequencing project was undertaken in the expectation that access to the complete protein coding repertoire of the organism will facilitate the search for vaccine candidate genes.

We used mRNA sequencing data from the GTEx project (V6, Supplementary Table 1 and 2), and the derived gene and transcript quantifications obtained on Gencode26 V19.

In addition to finding vaccine candidates, «the most striking feature of N. meningitidis from a genome perspective is that there are more contingency genes than any other bacterium or organism studied so far,» says Hervé Tettelin, leader of the N. meningitidis sequencing project at TIGR.

Even 30 years ago, it was obvious that Sanger sequencing had limited throughput, and a more efficient process could replace many tedious gene and genome mapping projects.

No doubt we'll be revisiting lung cancer, for which we sequenced candidate genes as part of the Tumor Sequencing Project (TSP) consortium.

«Before there was the Human Genome Project, people were studying gene sequences — they were just doing it a million different ways in a million different labs,» Huerta says.

The Comparative Mouse Genomics Centers Consortium (CMGCC) was initiated by the National Institute of Environmental Health Sciences» (NIEHS) Environmental Genome Project to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes.

Laboratory activities minimally include performing a lab - based patient - oriented research project applicable to cancer genomics, with an emphasis on mastering techniques commonly used within a human genetics laboratory, such as PCR, gene sequencing, mutation analysis, western blots, and functional protein studies.

At present we are engineering regulatory sequences to direct gene expression selectively to target cells and tissues in the CanEuCre / Pleiades Promoter Project.

Project Title: Using functional studies to explore potential high penetrance melanoma susceptibility genes identified using whole exome and genome sequencing.

NCBI provides Gene, Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), dbSNP (a database of single - nucleotide polymorphisms), the Reference Sequence Collection, a map of the human genome, and a taxonomy browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project.