Sentences with phrase «gene sequencing study»

«They're doing 50 genes rather than a whole exome» for a gene sequencing study.

«Gene sequencing study reveals unusual mutations in endometriosis: Findings advance search for new ways to classify aggressive forms of the disease.»

Not exact matches

June 19, 2013 — A Cornell University study offers further proof that the divergence of humans from chimpanzees some 4 million to 6 million years ago was profoundly influenced by mutations to DNA sequences that play roles in turning genes on and off.

In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS cases.

They aimed to extract ancient DNA from organisms trapped in amber to sequence extinct genes, recover dormant life forms and study protein evolution.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

Data published by the International Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.

It studies altered gene functions that are not due to a change in the DNA sequence, but may nevertheless be inherited.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

«Gene sequencing has opened a huge door to how complex these communities are,» says Patrick Seed, a Duke pediatrician specializing in infectious disease, who with biologist Rob Jackson is a lead investigator of the premature infant study.

Gene sequencing is also allowing Jackson and Seed to track down the sources of microbes, both benign and malignant, that find their way into the newborns in the study.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

The article constitutes the largest sequencing study to date on the genes of representatives from eight sponge genera covering all four currently recognized sponge classes.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

In a new study, researchers are taking joint biopsy tissue from patients at the start of a new therapy and then six weeks later to see if they can find a predictor gene sequence that will clearly identify which patients respond to a particular therapy.

A new study published in The Journal of Molecular Diagnostics has established that hybrid - capture sequencing is the method of choice for sequencing «actionable» gene mutations across the most common forms of lymphoid cancer.

In this study that used deep DNA sequencing of bacterial specific genes, the guts of both males and females exposed to lead had all of the similar complexity in microbiota as those not exposed.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

Traditional molecular systematic studies have progressed by sequencing genes one by one, a time - and cost - intensive task that has limited the amount of data a researcher could feasibly obtain.

With the state - of - the - art DNA sequencing technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related genes.

To confirm and strengthen the findings, Zwick and his team are currently performing an independent study of individuals with Down syndrome, using whole genome sequencing to further delineate alterations in genes that perturb heart development in children.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

Nucleic acid and protein sequences, as well as three - dimensional structures of proteins, are frequently the objects of study, but gene expression as well as the simulation of pathways and biochemical networks are attracting more and more attention.

Both studies relied on a popular lab organism known as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a sequenced genome showing that nearly half its genes are closely related to corresponding human genes.

«If we want to engineer the right microbiome to support plant growth, we need to understand the real function of the microbiome and not just sequence marker genes,» said study co-first author Asaf Levy, a research scientist at the JGI.

But it's very difficult if we don't have information about the optimum sequences for controlling genes,» says Dr Jae - Seong Yang, co-author of the study.

The unmapped DNA also sometimes resembles known, mapped genes, which can interfere in attempts to study similar sequences.

The study adds to evidence that gene editing may need to be adapted to each patient's genome, to ensure there aren't variants in DNA sequence in or near the gene being targeted that would throw off the technology.

To narrow down this time window, Whitfield studied sequences of three genes from 28 species of wasps — some virus - carriers and some not — and used differences among the species to build a family tree.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

To begin to grapple with those questions, the researchers involved in the new study first selected as «seeds» the nine genes that have been most strongly tied to ASDs in recent sequencing research from their labs and others.

Biotinylated probes are constructed based on these sequences to chemically «capture» the intron - containing genes from the study species» genome.

Because the mouse is so well studied, its sequence will speed the understanding of how our own genes work, says mouse geneticist Barbara Knowles, director of research at the Jackson Laboratory in Bar Harbor, Maine.

Using a battery of comparative tests to study the genome sequences of the giraffe and the okapi, the scientists discovered 70 genes that showed multiple signs of adaptations.

Wellems's team was studying chromosome 7 of P. falciparum in search of a gene that renders malaria resistant to the drug chloroquine, when they came across a cluster of five related genetic sequences.

In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.

To study gene expression, they then examined RNA sequencing data from 25 of the biliary - phenotype cancers and 44 hepatocellular cancers.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

The first study to sequence and analyze the entire genome of a HeLa cell line, along with access to its sequence data, has been published Aug. 7 in its final version, by G3: Genes Genomes Genetics, an open - access, scientific journal of the Genetics Society of America.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

Those few studies that have systematically compared individual gene sequences have shown that genes and the human genome may be much more variable than previously thought.

The researchers isolated and sequenced DNA from the mouse droppings, studying a gene often used to distinguish bacterial species to find out what gut bugs were present.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

The study, «Transcriptome Sequencing Implicates Dorsal Striatum - Specific Gene Network, Immune Response and Energy Metabolism Pathways in Bipolar Disorder,» [http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201694a.html] was supported by funding from the State of Florida.

The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.

Both studies rely on methods that attach molecular tags to all points in the genome where a double - stranded break has occurred, before sequencing the short, flagged segments to count the cuts in various genes.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

«Scientists sequence genomes of microscopic worms beneficial to agriculture: Study identifies gene families in five nematodes that are likely to be involved in parasitism.»

As Wroblewski, Parham, and co-authors explain in a PLOS Biology study published online today, they analyzed stool samples dating back 15 years and sequenced immune system genes from 125 chimpanzees.

Canadian researchers conducted a pilot study with 20 newborns to determine the effectiveness of a targeted next - generation sequencing panel that included all 4813 genes currently known to be associated with rare diseases.