Sentences with phrase «genes brain and behavior»

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Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years

Similar mechanisms are found in human brains — caregiver behavior matters for turning genes on and off.

With such an undeveloped little brain, they are about as close to their genes as any human will ever get and have little control over their behavior.

Dr. Giedd's research team seeks to use cutting edge technologies to explore the relationship between genes, brain and behavior in healthy development and in neuropsychiatric disorders of childhood onset.

We're funding researchers to investigate how drugs alter what genes are activated such that they modify the function of the cells, and how this, in turn, modifies the functions of brain circuits, and how that modifies behavior.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

The researchers found that adolescents who had a variation of another gene, which contributes to how quickly serotonin is recycled in the brain and which has been linked to hostile behavior in children, were more likely to exhibit signs of psychopathy.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

The results of this study not only advance science's understanding of the links between genes, the brain and behavior, but may lead to new insight into such disorders as autism, Down syndrome and schizophrenia.

Establishing links between genes, the brain and human behavior is a central issue in cognitive neuroscience research, but studying how genes influence cognitive abilities and behavior as the brain develops from childhood to adulthood has proven difficult.

Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia - like behaviors, brain changes and global gene expression in an animal model.

New research has found that the pharmaceuticals, which are frequently showing up in U.S. streams, can alter genes responsible for building fish brains and controlling their behavior

«In this study, we wanted to determine where in the brain this social behavior deficit arises and where and how increases of the UBE3A gene repress it,» said Anderson, who is also an Associate Professor in the Program in Neuroscience at Harvard Medical School and Director of Autism BrainNET Boston Node.

And individual genes in individual regions of the brain would start to show epigenetic alternations that would change the degree to which those genes were expressed, leading to changes in behavior and ultimately to the vulnerability to a drug of abuAnd individual genes in individual regions of the brain would start to show epigenetic alternations that would change the degree to which those genes were expressed, leading to changes in behavior and ultimately to the vulnerability to a drug of abuand ultimately to the vulnerability to a drug of abuse.

Hariri and his lab director, Daniel Weinberger, wondered if they could get more concrete answers by comparing people's genes not just to their behavior or a subjective psychological state, but to brain activity measured by a scan.

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

Nestler: The ability of this chronic social stress to produce maladaptive changes in brain and behavior are mediated through epigenetic modifications of gene expression in particular emotional centers of the brain.

«It alerts physicians to the relationship between genes, brain structure, and behavior,» a relationship that may one day become useful to clinicians.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown for the first time that ensembles of genes within the striatum — a part of the brain that coordinates many primary aspects of our behavior, such as motor and action planning, motivation and reward perception — could be deeply involved in the disorder.

Finally, the study provides an example of a highly integrative approach to understanding brain function at multiple scales, «linking genes and gene networks to the properties of single neurons and populations of neuron subtypes, all the way up to the level of animal behaviors,» said Okaty.

«But genes tied to autism tend to affect specific functions, such as the connections between brain regions that are essential to many human - specific behaviors, like speech and language.»

And included among the genes that follow this pattern is one that critically affects brain development and maternal care behaviAnd included among the genes that follow this pattern is one that critically affects brain development and maternal care behaviand maternal care behavior.

Now, researchers at the Institute for Comprehensive Medical Science, Fujita Health University, and ATR Computational Neuroscience Laboratories in Japan have succeeded in predicting states of mood - change - like behavior by studying the gene expression patterns in the brain in a bipolar disorder mouse model.

«The current results provide the evidence for a novel concept that some circadian genes and their regulatory machinery in the brain may be involved in the generation of infradian rhythm behavior,» Miyakawa explains.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Genes, Brain and Behavior 2010, 9, 562 - 574.

By blending classical and cutting - edge genetic approaches, Vivek Kumar, Ph.D.Researches behavior and behavioral abnormalities, including addiction, ADHD and depression, using mouse genetics as a platform.Vivek Kumar is unveiling the genes at work within the brain to control complex behaviors, such as anxiety and addiction.

Dr. Coyle's Laboratory for Psychiatric and Molecular Neuroscience takes advantage of insights into recently identified genes that confer risk for schizophrenia and related disorders and translates them into genetic mouse models to determine how these mutations affect brain changes as well as function, neurochemistry, and behavior.

Genes, Brain and Behavior, 13 (8), 743 - 757.

In their case, they focused on genes in the brain that play a role in behavior and mental health.

IBANGS members receive a free subscription to Genes, Brain and Behavior, which is published jointly by IBANGS and Wiley - Blackwell.

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I use epigenetic approach to identify the sexually dimorphic genes that control sexual differentiation in the mouse brain structure and behavior.

In a paper published in the latest issue of the neuroscience journal Neuron, McLean Hospital investigators report that a gene essential for normal brain development, and previously linked to autism spectrum disorders, also plays a critical role in addiction - related behaviors.

To truly understand and treat complex neuropsychiatric disorders, we need to know what behaviors are affected, which brain regions are involved, which genes, molecules, and cell types in these regions might be involved, and how the environment affects the propensity to develop these disorders.

We know a great deal about the genomic mechanisms through which androgens and estrogens influence behavior; by turning genes on and off and thus affecting levels of proteins in cells, they slowly sculpt the brain circuits and peripheral structures required to produce social output.

Meaghan Kennedy - «Neuropeptides and Social Behavior: Gene Sequences for Alternative Versions of the Vasotocin Receptor in the Goldfish Brain.»

Now that they know flies exhibit this time - coded behavior, Heisenberg and his colleagues can explore just what genes have created the capability, and how time functions in a fly brain.

«Having established that the normal gut flora could modify behavior and gene expression in key brain regions

Genes, Brain and Behavior, 8, 330 - 6.

'' [T] here might be a combination of genes acting together that somehow predispose us to have particular politics, presumably through their role in influencing our brains and thus our personalities or social behaviors..

Moreover, the patterns of activation and deactivation of brain regions in response to affective stimuli or in the course of mildly anxiogenic tasks vary quantitatively across subjects and can be predicted in part by individual differences in proneness to experience negative emotionality and anxiety, and by some polymorphic genes that influence behavior.

Defining the social phenotype in Williams syndrome: A model for linking gene, the brain, and behavior

Genes, Brain and Behavior, Vol.

Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years