Dorian Freudenreich (Brand, TUD)-- «
Genetic cell lineage tracing and transcriptome analysis of neuronal progenitor cells during neurogenesis and regeneration of the adult zebrafish telencephalon» (2010)
Not exact matches
With DNA evidence as solid as that used to convict criminals, researchers can trace the shared
genetic lineage of life's different branches back to the very base of the tree, some 4 billion years ago, when the interaction between primordial bacteria and viruses culminated in the «mother
cell,» the common ancestor of all life on Earth.
So confused is the
genetic history of llamas that some are in fact chimeras; they have
cells in their bodies from two distinct maternal
lineages.
Environmental and
genetic signals cue
cells as they differentiate into the many
lineages that recognize foreign antigens and fight off invaders
But when the daughter
cells are mated and
genetic reassortment takes place, they can subsequently pass along this same trait without the prion — that is, the trait becomes fixed in the
cell's
lineage and no longer depends on the prion state.
For example, cross-model comparisons may help to pinpoint key
cell types and molecules involved in
lineage decisions, reveal evolutionary inventions, and may allow to interpret
genetic disease models (for example in mouse) by mapping to human or other systems.
Our group pioneered the use of large - scale
genetic lineage tracing to quantify
cell behaviour in vivo.
Embryonic stem
cells, Adult stem
cells, Reprogramming to pluripotency and
lineage conversion, Directed differentiation, Germ
cells,
Genetic and epigenetic mechanisms, Stem
cells in development, Stem
cell niche, Cancer stem
cells, Disease modeling and drug screening, Stem
cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem
cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal
We use the Haplobank in reverse
genetic screens to investigate the temporal resolution of essential genes in mES
cells, and to identify novel genes that control sprouting angiogenesis and
lineage specification of blood vessels.