Sentences with phrase «genome wide association study»

Novel genes identified in a high - density genome wide association study for nicotine dependence

«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»

A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.

«We started with candidate gene studies, then moved to common variants and genome wide association studies, and then, most recently, leveraged exome sequencing, he said.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

These genes are usually found using genome wide association studies (GWAS) and GenoMEL is carrying out a very large study indeed.

Using individual - level data from 335,464 participants in the UK Biobank and summary association results from seven large - scale genome wide association studies, we examined the effect of this nitric oxide signaling score on cardiometabolic and other diseases.

Mapping hundreds of genetic variants through genome wide association studies provided an opportunity to gain insights into the pathobiology of immune mediated diseases.

Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large - scale genome wide association studies, gene - environement interaction studies, and pharmacogenetics.

Not exact matches

Her work has been funded by several NIH agencies and her current study, funded by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program, examines the interaction between genome - wide association and social environmental factors related to blood pressure among African American hypertensive parents and early risks for high blood pressure among their untreated children.

The study used Mendelian Randomization (MR) techniques to examine publicly available data from genome - wide association studies.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

In genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphisms).

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

The basis for this project was the GWAS Catalog, where the results of all published genome - wide association studies are recorded.

The researchers combined data from 22 genome - wide association studies including new data from around 35,000 migraine sufferers.

And he says that the genome - wide studies that failed to reproduce his results lacked sufficient power to reveal the association between TOMM40 and Alzheimer's disease.

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

In their investigations or so - called genome - wide association studies, the team of researchers compared the genetic profile of study participants to the forced vital capacity (FVC), a volume parameter of lung function.

The University of Edinburgh scientists examined genomic and health data from over 52,000 male participants of the UK Biobank, performing a genome - wide association study of baldness.

A second, genome - wide association study scanned the genome for common variants behind autism in more than 10,000 affected children, their families, and controls.

Genome - wide association studies are notoriously weak in identifying variants that strongly determine our health.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Available in Volume 168, Issue 8 of the American Journal of Medical Genetics: Neuropsychiatric Genetics, the paper, titled, «Using the Coriell Personalized Medicine Collaborative Data to Conduct a Genome - Wide Association Study of Sleep Duration,» draws on data collected from Coriell study participants to establish its findStudy of Sleep Duration,» draws on data collected from Coriell study participants to establish its findstudy participants to establish its findings.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

All of these studies were genome - wide association studies (GWAS) based on millions of genetic variants called Single Nucleotide Polymorphisms (SNPs).

The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.

The software allowed them to compare the results of the more than 1,400 genome - wide association studies (GWAS) that have been published on the topic so far.

Interestingly, a variant of the WNT10A gene associated with lower levels of its protein's expression has been linked to a greater likelihood of male pattern baldness, according to a recent genome - wide association study.

«Together with a previously published genome - wide association study, our findings suggest that lower levels of WNT10A may contribute to male pattern baldness in some individuals.»

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

The Wellcome Trust, the U.K.'s largest biomedical charity, began to put its weight behind genome - wide association studies in 2005 and recruited 200 researchers to analyze the DNA of 17,000 people from across the United Kingdom.

Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.

Genome - wide association studies generally rely on genetic variations called single - nucleotide polymorphisms, or SNPs (pronounced «snips»).

Genome - wide association studies, which try to find correlations between particular genetic variations and disease diagnoses, are a staple of modern medical research.

The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent cohorts of patients with IBS and control subjects.

Fugger hopes that his team's study will also help to dispel the notion that genome - wide association studies will never offer much that can be used in patient care (see «Human genetics: Hit or miss»).

The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such as gene sets produced from genome - wide association studies (GWAS) and differential expression analysis.

Genome - wide association studies of eating disorders in humans have been limited in their power to detect significant associations between genotype and disease or disease traits such as binge eating.

Nestadt and his team conducted what is known as a genome - wide association study, scanning the genomes of more than 1,400 people with OCD and more than 1,000 close relatives of people with the mental disorder.

In their new study, the team performed a genome - wide association study (GWAS) on a cohort of 235 Labrador retrievers, together with an independent replication cohort.

Nestadt says the genome - wide association study findings of a PTRPD - OCD link add to evidence that the genetic region they identified is important.

The genome - wide association study, conducted by a UCL - led collaboration of 65 academics in 11 countries and funded by Alzheimer's Society and the Lewy Body Society, is published in The Lancet Neurology.

«Face shape is in the genes: Genome - wide association study identifies genetic variants that contribute to healthy facial traits.»