Sentences with phrase «genome wide analysis»
Large scale sequencing approach and genome wide analysis can be applied on different economic crops for better understanding their evolutionary process and specific traits, providing unique opportunities for further applications.»
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Among individuals with two divergent mitochondrial haplotypes (mt - haplotypes), the genome - wide analyses revealed significant differences in nuclear allele frequencies.
Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.
Collaborative genome - wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»
While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.
The genome - wide analyses showed that Cpf1 was highly specific, showing fewer off - target cleavage sites (6 for LbCpf1 and 12 for AsCpf1), compared to Cas9, cleaving at > 90 sites in the human genome (Fig. 1a).
The researchers performed genome - wide analysis of nasal epithelial cells collected from children experiencing acute asthma exacerbation.
«Genome - wide analysis allowed us to identify a gene, VNN - 1, whose expression discriminated between good and poor responders to systemic corticosteroid treatment,» said Gurjit Khurana Hershey, MD, PhD, senior author and director of Asthma Research at Cincinnati Children's.
Researchers from Boston University School of Medicine looked for new stroke genes using genome wide association as well as meta - analysis.
To identify the genes that give rise to the palette of human skin tones, Crawford et al. applied genome - wide analyses across diverse African populations (see the Perspective by Tang and Barsh).
They also performed comparative and genome - wide analyses, which provide insights into the evolutionary history of Asterids, a subgroup of flowering plants that includes potatoes, tomatoes and coffee.
The researchers, including postgraduate students Miaolin Chen at Shanghai Jiao Tong University and Deborah Devis at the University of Adelaide's Waite campus, performed a genome - wide analysis of potential pollen allergens in two model plants, Arabidopsis thaliana (thale cress) and rice by comparing those results among 25 species of plants ranging from simple alga to complex flowering plants.
«In the current study, using a genome - wide analysis of DNA methylation, we identified a few PPARα target genes that underwent ligand - activated PPARα - dependent DNA demethylation during the perinatal period and whose DNA methylation status persists into adulthood,» explains a corresponding author Koshi Hashimoto.
In their work, Dr. Lessnick and his team used bioinformatics analysis of experimental data in an unbiased genome - wide approach.
Conducting the first large - scale, genome - wide analyses of ancient human remains from the Near East, an international team led by Harvard Medical School has illuminated the genetic identities and population dynamics of the world's first farmers.
Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.
New technologies that are slashing the costs of sequencing and genome analyses will make possible the simultaneous genome - wide search for SNPs and other DNA alterations in individuals.
To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.
The second tool, SuperExactTest, establishes the very first theoretical framework for assessing the statistical significance of multi-set intersections and enables users to compare very large sets of data, such as gene sets produced from genome - wide association studies (GWAS) and differential expression analysis.
Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.
They then used genome - wide analysis to search for genes switched on by KLF4 at a late stage of reprogramming.
Scientists sequenced the complete Arabidopsis genome in 2000, making genetic analysis relatively easy; and, with many populations growing throughout the world, thale cress has a wide range of genetic variety.
Their analysis also considered results from two earlier genome - wide association studies and confirmed certain previous findings.
Corresponding author, Dr Seth Weinberg says «Our analysis identified several genetic associations with facial features not previously described in earlier genome - wide studies.
«Underpinnings of drought tolerance in plants: Genome - wide analysis elucidates drought - tolerance system in Arabidopsis.»
According to Paek, «Genome - wide transcriptome analysis using drought - tolerant or - susceptible variants is a promising method to reach the goal of understanding drought tolerance».
His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.
The researchers say this is the first study to ever do such a genome - wide association analysis for an infectious disease.
Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
«This was what you call a sort of fast - track phase,» Hakonarson says about the new study, in which he and his team identified and characterized only the strongest signals in the genome - wide analysis.
Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.
Dr Chuya Shinzato, first author of the study, «Genome - wide SNP analysis explains coral diversity and recovery in the Ryukyu Archipelago».
«The results of our study speak to the evolutionary origins of obesity and provide new targets to understand the polygenic nature of obesity in a unique model system,» according to the study, «Genome - Wide Analysis of Starvation - Selected Drosophila melanogaster — A Genetic Model of Obesity.»
In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.
Genome - wide analysis of variance (ANOVA) revealed that germline SNPs / CNVs and somatic CNAs influenced > 39 % of gene expression probes, roughly half acting in cis and half in trans.
To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome - wide analyses and chemical biology.
Yet it is small enough for high - resolution genome - wide analysis.»
An unbiased genome - wide analysis of zinc - finger nuclease specificity.
Proteomics (Fagerberg et al, «Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics») with a focus in the article on the tissue - specific pattern in the human body.
A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA «combing», as well as high throughput sequencing approaches such as DNA - seq for mutation landscape analyses, RNA - seq for transcriptome analyses and ChIP - seq mapping of chromatin - associated proteins and their genome - wide modulation in response to DNA damages.
Microarray analysis was performed at different time points to determine yeast genome - wide response when exposed to salt, acid, hypoxic conditions, and hydrogen peroxide, as well as ethanol, isopentenol, and other biofuels candidates.
Birgit Kagermeier - Schenk (Weidinger, TUD)-- «Genome - wide analysis of Wnt / beta - catenin target genes in zebrafish embryogenesis and characterization of a novel modifier of Wnt signaling pathways» (2010)
It was identified using a genome - wide linkage analysis of patients who suffered from stroke, using a broad but rigorous definition of the disease.
Julia Winter (Zerial, MPG)-- «Genome - wide analysis of membrane trafficking in polarised epithelial cells in the C.elegans intestine» (2008)
This issue was identified by follow - up on likely «false - positive» genetic associations with genome - wide statistical significance in case - control analysis.
Genome - wide analyses showed a Wnt3a - dependant release of Setdb1 from the promoter of selected target genes upon myoblast terminal differentiation.
Genome - wide genetic analysis of polyploidy in yeast.
Genome - wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules.
A systematic genome - wide analysis of zebrafish protein - coding gene function.