Sentences with phrase «genomic sequences reveal»

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Age - related variations in DNA methylation were analyzed by deep sequencing technology, which revealed distinct patterns, with gains in methylation in older individuals occurring at genomic sites that were unmethylated in young individuals, and vice versa.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

Recently, cultivation - independent sequencing methods have produced a wealth of genomic data for previously unidentified archaeal lineages, several of which appear to represent newly revealed branches in the tree of life.

Many researchers now believe that real advances in genomics will come not from simple X-causes-Y correlations but from a rich statistical understanding that emerges out of the sequences of millions of genomes — a set that reveals how our genetic code is likely to interact with the environment to make us who we are.

Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation.

Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species

Analysis of genomic, epigenetic, and RNA sequencing data revealed that the combinations of mutations that lowered the levels of functioning BRCA1 and BRCA2 RNA — genes that produce the breast cancer tumor suppressor proteins — were associated with significantly better survival outcomes.

The results, published in the journal Nature Biotechnology, reveal that the small, accessible and cost effective technology could revolutionize genomic sequencing.

The unusually high death rate (83 %) makes titi monkeys unlikely to be natural hosts for TMAdV, and the genomic sequence of TMAdV revealed that it is very different from any other known adenovirus.

Genomic signatures reveal some of the evolutionary forces acting on a particular genetic sequence — or the entire genome.

In yeast and Caenorhabditis elegans, the majority of ORFs revealed by genomic sequencing have not been associated with mutant phenotypes, even in genomic regions that have been subjected to saturation mutagenesis (36 - 37).

Genomic sequencing of the isolated virus revealed that it is closely related to Tembusu virus (a mosquito - borne Ntaya group flavivirus), with 87 — 91 % nucleotide identity of the partial E (envelope) proteins to that of Tembusu virus and 72 % of the entire genome coding sequence with Bagaza virus, the most closely related flavivirus with an entirely sequenced genome.

Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes.

Although the diversity of sponges and their uncertain phylogeny make it doubtful that any single species can reveal the intricacies of early animal evolution, comparison of the A. queenslandica draft genome with sequences from other species can provide a conservative estimate of the genome of the common ancestor of all animals and the timing and nature of the genomic events that led to the origin and early evolution of animal lineages.

Analysis of viral genomic and human mitochondrial sequences revealed that all previously characterized XMRV strains are identical and that the archival RNA had been contaminated by an XMRV - infected laboratory cell line.

The 97 - megabase genomic sequence of the nematode Caenorhabditis elegans reveals over 19,000 genes.

In the postgenomic era, the availability of human genome sequence for genome - wide analysis has revealed higher - order architectural features (i.e., beyond primary sequence information) that may cause genomic instability and susceptibility to genomic rearrangements.

Next - generation medical imaging and genomic sequencing have all helped to reveal that some foods are neuroprotective, literally shielding the brain from harm and supporting cognitive fitness over the course of a lifetime.