Sentences with phrase «gladstone senior»

«We hope our human model of ALS will help us to move quickly and effectively to identify promising therapeutic candidates for ALS,» said Gladstone Senior Investigator Steve Finkbeiner, MD, PhD, who is also a professor of neurology and physiology at the University of California, San Francisco, with which Gladstone is affiliated.

SAN FRANCISCO, CA — Gladstone Senior Investigator Katerina Akassoglou, PhD, was awarded a prestigious multi-year, multi-million dollar grant from the National Institute of Neurological Disorders and Stroke (NINDS).

On the left, Gladstone Senior Investigator, Shinya Yamanaka, MD, PhD, receives the 2012 Nobel Prize in Physiology or Medicine from Sweden's King Carl Gustaf on December 10, 2012, in Stockholm, Sweden, and, on the right, Dr. Yamanaka shows his Nobel Prize medal during the Nobel Prize Award ceremony.

In 2006, Gladstone Senior Investigator Shinya Yamanaka, MD, PhD, discovered he could make stem cells — dubbed induced pluripotent stem cells (iPSCs)-- by treating ordinary skin cells with four key proteins.

Gladstone Senior Investigator Nevan Krogan, PhD, is studying how the proteins in neurons interact with each other and how mutations in the proteins lead to autism.

Gladstone Senior Investigator Katerina Akassoglou, PhD, was awarded a prestigious multi-year, multi-million dollar grant from the National Institute of Neurological Disorders and Stroke (NINDS).

In two studies published in Science and Cell Stem Cell, the team of scientists, who were led by Gladstone senior investigator Sheng Ding, PhD, and are part of the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, used chemical cocktails to gradually coax skin cells to change into organ - specific stem cell - like cells and, ultimately, into heart or brain cells.

Also contributing to the understanding of brain function, Gladstone Senior Investigator Anatol Kreitzer, PhD, studies the connections neurons make with each other in the brain.

Gladstone Senior Investigator Todd McDevitt, PhD, was recently appointed to two new positions within the joint Graduate Program in Bioengineering (BioE) from UC Berkeley (Berkeley) and UC San Francisco (UCSF).

iPSCs were discovered by Gladstone Senior Investigator and Prize namesake Shinya Yamanaka, MD, PhD.

In the latest issue of Developmental Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, describe the precise order and timing of signals that spur the formation of arteries.

The team, led by Gladstone Senior Investigator Anatol C. Kreitzer, PhD, was trying to understand the basic mechanisms of the basal ganglia, which are a group of interconnected neurons in the brain that control movement and are associated with decision - making and action selection.

Recently, Gladstone Senior Investigator Yadong Huang, MD, PhD, found that a drug used for years to treat heart failure also seems to reverse signs of Alzheimer's disease in both human and mouse brains.

Then last year, Gladstone Senior Investigator Sheng Ding, PhD, announced that he had used a combination of small molecules and genetic factors to transform skin cells directly into neural stem cells.

Today, researchers in the laboratory of Gladstone Senior Investigator Lennart Mucke, MD, report in Nature Neuroscience that DSBs in neuronal cells in the brain can also be part of normal brain functions such as learning — as long as the DSBs are tightly controlled and repaired in good time.

In a study being published online today in the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a heart.

In this research, Dr. Finkbeiner and others took advantage of advanced «reprogramming» techniques pioneered by Gladstone Senior Investigator Shinya Yamanaka, MD, PhD.

The Key Is the Short Form «Our discovery was born out of frustration,» explained Gladstone Senior Investigator Melanie Ott, whose study was published today in the journal Molecular Cell.

«Support from your partner is crucial for anyone who wants to achieve success in a difficult career like this one,» said Yamanaka, Gladstone senior investigator.

In part, the Center builds on pioneering work done by Gladstone Senior Investigator Shinya Yamanaka, MD, PhD — who currently divides his time between Gladstone and Kyoto University's Center for iPS Cell Research and Application (CiRA).

Over the past several years, much of our work has expanded on the discovery by Shinya Yamanaka, MD, PhD, a Gladstone Senior Investigator.

It is a huge jump forward from previous genome editing techniques,» said Gladstone Senior Investigator Bruce Conklin, MD, an early adopter of the technology.

Writing in the latest issue of the journal Nature, researchers in the laboratories of Gladstone Senior Investigator Sheng Ding, PhD, and UCSF Associate Professor Holger Willenbring, MD, PhD, reveal a new cellular reprogramming method that transforms human skin cells into liver cells that are virtually indistinguishable from the cells that make up native liver tissue.

«Over the course of a person's life, with repeated exposure to bacteria and viruses, these T cells mature and eventually lose a protein called CD28,» said Gladstone Senior Investigator Melanie Ott, senior author of the new study.

«Our findings could have a significant impact on the treatment of autoimmune diseases, as well as on stem cell and immuno - oncology therapies,» said Gladstone Senior Investigator Sheng Ding, PhD, who is also a professor of pharmaceutical chemistry at the University of California, San Francisco.

Not exact matches

«The reticular thalamus acts like a gate that filters information from the thalamus and dispatches signals to the cortex,» explained Jeanne Paz, PhD, assistant investigator at Gladstone and senior author of the new study.

Sheng Ding, PhD, a senior investigator in the Roddenberry Stem Cell Center at Gladstone and co-senior author on the study, adds, «This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.

«If you do this enough times, and deplete the pool of latently infected cells, you could potentially cure patients from infection,» says Eric Verdin, a senior investigator at the Gladstone Institute of Virology and Immunology at the University of California, San Francisco.

Shinya Yamanaka, MD, PhD, a UCSF professor of anatomy and a senior investigator with the UCSF - affiliated Gladstone Institutes, as well as the director of the Center for iPSCell Research and Application (CiRA) and a principal investigator at Kyoto University, shared the Nobel Prize in 2012 for discovering how to make iPS cells from skin cells using a handful of protein «factors.»

Senior author on the paper, Deepak Srivastava, MD, director of cardiovascular and stem cell research at Gladstone and a pediatric cardiologist at the University of California San Francisco (UCSF), had previously discovered that disruption of one of two copies of a master gene called NOTCH1 can cause valve birth defects and CAVD.

«We thought it might be important to look instead at the toxic environment outside the cell, where blood proteins accumulate» said Akassoglou, senior investigator at Gladstone, professor of neurology at UC San Francisco (UCSF), and senior author of a study published by the scientific journal Neuron.

«Our findings have provided us not only with a new perspective on the role of astrocytes in cognition, but also with an exciting drug target to enhance memory and maybe even stave off memory decline in Alzheimer's disease,» says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease and professor of neurology and neuroscience at the University of California, San Francisco.

«It would really be wonderful if tau reduction turned out to be useful not only in Alzheimer's disease, but also in other disabling neurological conditions for which there currently are no effective treatments,» said senior author Lennart Mucke, MD, the director of the Gladstone Institute of Neurological Disease and a professor of Neurology and Neuroscience at the University of California, San Francisco.

«Interneurons can reroute after spinal cord injuries, which makes them a promising therapeutic target,» said senior author Todd McDevitt, PhD, a senior investigator at Gladstone.

«The robustness of the effect is quite remarkable,» says senior author Katerina Akassoglou, PhD, a senior investigator at Gladstone.

«The beauty of this technique is that it is very easy and robust, but it still allows you to create three - dimensional miniature tissues that function like normal tissues,» said senior author Bruce Conklin, MD, a senior investigator at Gladstone.

«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.

Pollard, senior investigator at the Gladstone Institutes and professor of epidemiology and biostatistics at the University of California, San Francisco, delivered a presentation titled «Estimating Taxonomic and Functional Diversity in Shotgun Metagenomes» during an invited session focused on statistics, the microbiome and human health.

Steve Finkbeiner, MD, PhD, senior investigator and director of the Taube - Koret Center for Neurodegenerative Disease Research at Gladstone Institutes, is part of this Huntington's disease research program.

After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991.

«Depressive symptoms are associated with sexual practices that increase risk for HIV acquisition,» said first author Patricia Defechereux, PhD, a senior research associate at the Gladstone Institutes.

Steven Finkbeiner, MD, PhD, a director and senior investigator at the Gladstone Institutes, teamed up with computer scientists at Google.

GC3 is a 10 - year initiative, launched in 2017 by Founding Director Leor Weinberger, PhD, senior investigator at Gladstone, William and Ute Bowes Distinguished Investigator, and professor of pharmaceutical chemistry, biochemistry and biophysics at UC San Francisco (UCSF).

Senior Investigator, Gladstone Institute of Neurological Disease Director, Center for Translational Advancement

Senior Investigator, Gladstone Institute of Cardiovascular Disease Program Director, Bioengineering Graduate Program, UCSF and UC Berkeley

Senior Investigator, Gladstone Institute of Neurological Disease Program Director, Neuroscience Graduate Program, UCSF

Srivastava, who pioneered the use of stem cells for heart disease, is director of the Roddenberry Stem Cell Center and a senior investigator at the Gladstone Institutes.

Dr. Greene, a senior investigator at Gladstone, was elected a member of the AAP in 1990.

«Most genetic mutations that are associated with disease occur in enhancers, making them an incredibly important area of study,» said senior author Katherine Pollard, PhD, a senior investigator at the Gladstone Institutes.

«Viruses are fantastic tools for shedding new light on human biology,» says Nevan Krogan, PhD, a senior investigator at the Gladstone Institutes and a corresponding author on both papers.