«When we injected GMT into each of the three types of human fibroblasts, nothing happened — they never transformed — so we went back to the drawing board to look for additional genes that would help initiate the transformation,» said
Gladstone Staff Scientist Ji - dong Fu, PhD, the study's lead author.
«Vegf sets off a signaling cascade that eventually activates a group of proteins, called Mitogen Activated Protein Kinases, or MAPKs,» said
Gladstone Staff Scientist Joshua Wythe, PhD, the paper's lead author.
Gladstone Staff Scientist Sami Barmada, MD, PhD, and Gladstone Associate Investigator Nevan Krogan, PhD, also participated in this research.
«The accelerator circuit gives CMV the powerful strategic advantage to outpace immune defense systems,» said
Gladstone Staff Scientist Cynthia Bolovan - Fritts, PhD, the paper's other lead author.
Not exact matches
«This was strange because it meant that, contrary to what we believed, MYC isn't necessary for cells to reprogram efficiently,» said Tim Rand, MD, PhD,
staff scientist at
Gladstone and a first author of the study.
«Our results provide the first evidence that blood promotes T cell responses against the brain,» says first author Jae Kyu Ryu, PhD, a
staff research
scientist at the
Gladstone Institutes.
«I am especially excited about the improvements we observed in cognitive and behavioral dysfunctions because these abnormalities are particularly hard on the kids — and their parents,» said first author Ania Gheyara, MD, PhD, a
staff scientist at
Gladstone who is also affiliated with the UCSF Department of Pathology.
Supported by state - of - the - art core facilities and professionally trained
staff,
Gladstone scientists rely on the latest technologies to advance their work.
«Some family members with the same number of repeats experience the onset of symptoms at different ages,» shared Julia Kaye, PhD, a
staff research
scientist at
Gladstone who will help lead the scientific efforts.
«We detected heightened thrombin activity at specific disease «hot - spots,» regions where neuronal damage developed over time,» said
Gladstone Staff Research
Scientist Dimitrios Davalos, PhD, associate director of the CIVIR and one of the paper's lead authors.
«We found that people who carry progranulin mutations were nearly twice as likely to have retinal lipofuscin deposits than healthy people,» shared Michael Ward, MD, PhD, a former
staff scientist at
Gladstone and lead author of the study, as well as adjunct assistant professor of neurology at UCSF.
«We showed the fast - spiking interneurons act like gatekeepers for plasticity,» said Scott Owen, PhD,
staff scientist in Kreitzer's laboratory at
Gladstone.
Po - Lin So, a project manager and
staff research
scientist at
Gladstone, describes how her love of science began in elementary school and continued to grow as she advanced academically and professionally.
«The SMDC has provided excellent services for
scientists at
Gladstone, but we were often waiting for access to their equipment and
staff,» said Anke Meyer - Franke, PhD, a
staff research
scientist at
Gladstone.
says author Alexander Pico, PhD, a
staff research
scientist at the
Gladstone Institutes.
But in their latest research, Dr. Finkbeiner and his research team, including
Gladstone Staff Research
Scientist Gaia Skibinski, have focused their attention on LRRK2 — the most common genetic cause of Parkinson's.