Sentences with phrase «gliosis in»

For measures of gliosis in Grn − / − mice, we also reported the power to detect normalization of gliosis.

We therefore anticipated some improvement of gliosis in Grn − / − mice.

Not exact matches

Müller glia are activated in almost all types of retinal disease, also called gliosis.

Since the TMEM106B genetic variant on brain aging was also apparent in patients with Alzheimer's disease, Rhinn explained that «one interpretation is that TMEM106B is a critical element of a resilience network in the frontal cortex that limits the extent of neuronal loss and gliosis.»

In essence, most pathological conditions in the mammalian retina lead to changes in Müller glia — often called reactive gliosis, which might be analogous to the response of astrocytes upon injury of other brain regionIn essence, most pathological conditions in the mammalian retina lead to changes in Müller glia — often called reactive gliosis, which might be analogous to the response of astrocytes upon injury of other brain regionin the mammalian retina lead to changes in Müller glia — often called reactive gliosis, which might be analogous to the response of astrocytes upon injury of other brain regionin Müller glia — often called reactive gliosis, which might be analogous to the response of astrocytes upon injury of other brain regions.

Grn − / −, but not Grn + / − mice, develop progressive gliosis, inflammation, and lipofuscinosis in several brain regions that first becomes detectable around 6 — 7 months of age and is more strongly elevated by 12 months (Ahmed et al., 2010; Yin et al., 2010; Wils et al., 2012; Filiano et al., 2013; Götzl et al., 2014).

We therefore included Grn − / − mice in the study to test the secondary hypothesis that exercise could improve gliosis independent of any effect on progranulin expression.

Recent studies have suggested that cholinergic modulation is involved in neuroinflammatory cellular reactions including neurogenesis and gliosis, and in memory improvement.

In addition, the hippocampus of T2DM - AD - Vehicle mice showed increased proinflammatory cytokines IL - 1β and TNF - α and gliosis, and rivastigmine treatment blocked these inflammatory reactions.

Grn − / − mice were included in the study to test for progranulin - independent benefits of exercise on gliosis.

Although it was not the primary endpoint of our analyses, we took the opportunity to assess whether exercise, which is known to have anti-inflammatory effects, might reduce gliosis and inflammation in Grn − / − mice, which would be independent of an effect on progranulin levels.

(2009) Tempering Gliosis by Inhibition of the NFkB Pathway in an Acute Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2781).

(2010) Decreasing Gliosis by Inhibition of the Stat3 Pathway in a Microbead Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3192).