Selenium helps protect against iodine toxicity by ensuring that
glutathione peroxidase activity in the thyroid is adequate to avoid cytotoxicity of hydrogen peroxide (34).
Savic - Radojevic A, Bozic Antic I, Coric V, Bjekic - Macut J, Radic T, Zarkovic M, Djukic T, Pljesa - Ercegovac M, Panidis D, Katsikis I, Simic T, Macut D. Effect of hyperglycemia and hyperinsulinemia on
glutathione peroxidase activity in non-obese women with polycystic ovary syndrome.
A study in Africa showed that two months of selenium supplementation restored
the glutathione peroxidase activity and improved thyroid function through increased conversion of T4 to the active T3.
Not exact matches
As a result, the
activities of the antioxidant enzymes
glutathione peroxidase and catalase were restored, ROS levels decreased, and the bacterial biofilm disintegrated in the wound — all of which resulted in the development of healthier wound tissue and led to wound healing.
This study investigated the influence of chronically administered curcumin on normal ageing - related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation,
activities of the enzymes superoxide dismutase (SOD),
glutathione peroxidase (GPx), and Na (+), K (+), - adenosine triphosphatase (Na (+), K (+), - ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6 - and 24 - month - old rats.
Low levels of
glutathione peroxidase 1
activity in selenium - deficient mouse liver affect c - Jun N - terminal kinase activation and p53 phosphorylation on Ser - 15 in pro-oxidant-induced aponecrosis.
The blood glucose, plasma insulin, hemoglobin, glycated hemoglobin,
activities of the various antioxidant enzymes (catalase, superoxide dismutase,
glutathione peroxidase and
glutathione reductase) and lipid peroxidation markers (malondialdehyde, hydroperoxides and conjugated dienes) were evaluated in all the groups.
It also quite powerfully stimulates the immune system, increases disease - fighting white blood cell production and
activity, and elevates levels of superoxide dismutase and
glutathione peroxidase, two of the most powerful antioxidants and health - promoting substances known to man, which likely have quite a bit to do with its longevity - enhancing properties.
Since
glutathione peroxidase is made of selenium, the enzyme
activity will be compromised when selenium is depleted.
The results indicated that - «Curcumin treatment (80 mg kg − 1 b.w. daily for 3 days, orally) was found to have a protective effect on mercury - induced oxidative stress parameters, namely, lipid peroxidation and
glutathione levels and superoxide dismutase,
glutathione peroxidase and catalase
activities in the liver, kidney and brain.»
Moreover, a decrease in the
activity of plasma
glutathione peroxidase observed in the glucose - fed rats was prevented by lipoic acid treatment.
Glutathione peroxidase 1
activity was affected by sex and smoking status but retained its predictive power in these subgroups.
Glutathione peroxidase 1
activity was among the strongest univariate predictors of the risk of cardiovascular events, whereas superoxide dismutase
activity had no association with risk.
After adjustment for these and other cardiovascular risk factors, the inverse association between
glutathione peroxidase 1
activity and cardiovascular events remained nearly unchanged.
Magnesium has also been found to increase the
activity of
glutathione peroxidase — the enzyme that is responsible for keeping our cells protected from damage.
Kankofer M, Wawrzykowski J, Giergiel M. Sex - and age - dependent
activity of
glutathione peroxidase in reproductive organs in pre - and post-pubertal cattle in relation to total antioxidant capacity.