Not exact matches
The test, which could be available to patients within two years, identifies the chemical signatures found in the plasma of blood joint
proteins damaged by oxidation, nitration and
glycation; the modification of
proteins with oxygen, nitrogen and sugar molecules.
Advanced
glycation end - products promote oxidative
damage to
proteins, lipids and nucleotides.
Glycation causes
damage to the body's
proteins, which can result in inflammatory diseases like arthritis, fibromyalgia, and dementia.
These
damaged proteins are called advanced
glycation end products (AGEs).
Elevated blood sugar leads to
glycation (basically, oxidation and caramelization of blood sugars), which leads to sticky sugar -
protein and sugar - lipid complexes that
damage the lining of the blood vessels and other organs leading to their dysfunction.
The biological mechanisms of lifespan extension through calorie restriction are not fully understood, but researchers say it may involve alterations in energy metabolism (as mentioned above), reduced oxidative
damage, improvements in insulin sensitivity, reduction of
glycation, modulation of
protein metabolism, downregulation of pro-inflammatory genes and functional changes in both neuroendocrine and autonomic nervous systems.
Increases advanced
glycation end products wherein sugar molecules attach to
proteins and end up
damaging them
Surplus glucose relentlessly reacts with your body's
proteins, causing
damaging glycation reactions while fueling the fires of chronic inflammation and inciting the production of destructive free radicals (Basta 2004; Uribarri 2005; Toma 2009).
In addition, to stop the
damaging «
glycation» reactions that can take place when dietary carbohydrates react with
proteins in the body, you can also take about 50 - 100 mg daily of vitamin B6 pyridoxine, which most multi-vitamins contain (and meal replacement powders like LivingFuel SuperGreens).
The high blood sugar causes
damage to
proteins (AGE or Advanced
Glycation End - Products), which then raise the risk of dying.
As a bonus, olive leaf extract protects against the
damage of high blood sugar — against advanced
glycation end products (AGEs), free radicals which form when elevated blood glucose levels react with
proteins and run wild.