Gonadotropin receptors have been identified in some extragonadal tissues.
Significance of the carbohydrate moiety of the rat ovarian luteinizing - hormone / chorionic -
gonadotropin receptor for ligand - binding specificity and signal transduction
Not exact matches
Overweight / obese males showed accelerated aromatization of androgens to estrogens, inhibiting
gonadotropin secretion by activation of estrogen
receptors (ERs) of the hypothalamus that promote hypogonadism (78).
Synthesis and evaluation of novel
gonadotropin - releasing hormone
receptor - targeting peptides.
«These results suggest that phytoestrogens can interfere with the normal estrogen feedback mechanisms with respect to release of
gonadotropin in the ewe... although most studies into the effects of phytoestrogens have concentrated on changes in the reproductive tract, there are indications that they interfere with the hormone balance between the ovaries and the hypothalamo - adenohypophysical system... ewes on phytoestrogens have shown follicular abnormalities such as numerous small follicles, deficient antrum formation and signs of early atresia... it is possible that the permanent changes brought about by phytoestrogens in the brain are a result of these compounds interacting with estrogen
receptors in this tissue, and subsequently influencing the re-synthesis or replenishment of cyto - plasmic estrogen
receptors... phytoestrogens can interfere with the delicate feedback mechanisms involved in the release of the gonadotrophins.»
This may reflect a particular sensitivity of
receptor sites of some potentially metastatic cancer cells to gonadal hormone removal and / or prolonged levels of the
gonadotropin hormone, follicle stimulating hormone [28].
Danazol or GnRH Analogues — Danazol, no longer widely used, is an androgenic agent; GnRH stands for «
gonadotropin - releasing hormone,» and such analogues affect
receptors in the pituitary gland.