There is high diversity of studies, with a high abundance of
gut microbiome studies, a few publications on fecal transplant, and some very interesting early life / pregnancy / mother - infant science.
The position will provide a unique and multidisciplinary exposure to in vivo
gut microbiome studies, lipid / lipoprotein metabolism, metabolomics, and drug development.
This workshop targets microbiologists, bioinformaticians and physicians, in order to favor the translational applications of
the gut microbiome studies.
Not exact matches
Some small
studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the
gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.
Biotech's Encouraging Phase 2
Gut Microbiome Data «Bodes Well» for Phase 3 Source: Streetwise Reports (3/14/18) H.C. Wainwright & Co. analyst Ram Selvaraju reported the latest
study findings involving this biotherapeutic firm's lead asset.
DuPont Nutrition & Health (DuPont) released the findings of a research
study showing that DuPont ™ Danisco ® Litesse ® Ultra ™ polydextrose alters the
gut microbiome.
Even in IBD patients, who have a very messed up
microbiome (a finding of the American
Gut data), the benefits of antioxidant therapy is well documented (see below
studies).
Previous
studies have shown that a high fat maternal diet during gestation and lactation has a long - term impact on the infant's
gut microbiome (the community of bacteria living inside the human
gut.)
Some
studies have also linked the
microbiome to human mood and behavior as well as
gut health, human development, and metabolic disorders.
«Further
studies are needed to delineate if specific changes in maternal diet during breast - feeding alter the infant
gut microbiome and to determine if this results in any health consequences for the infant,» said Kristen Meyer, in the Department of Obstetrics and Gynecology at Baylor College of Medicine and the presenter of the
study at the SMFM annual conference.
Given that these two components of breast milk have the potential to alter the
gut microbiome of breast - feeding infants, the results of the
study suggest that development of the infant
gut microbiome may be affected in part by what the mother eats during breastfeeding.
In a
study to be presented Thursday, Jan. 26, in the oral plenary session at 1:15 p.m. PST, at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, researchers with Baylor College of Medicine, Houston, Texas and University of California, San Diego, La Jolla, California, will present their findings on a
study titled, Maternal Diet Structures the Breast Milk
Microbiome in Association with Human Milk Oligosaccharides and
Gut - Associated Bacteria.
In addition, many
studies do not take into account the complex interaction of different fatty acid subtypes, such as omega - 3 and omega - 6 fatty acids, on
gut inflammation as well as their effect on the intestinal
microbiome.
An emerging body of literature in adults has begun to establish clear associations between
gut microbiome composition and a wide range of health outcomes.1 - 6 In contrast, comparatively little is known about the
gut microbiome in infants and children, the exposures that shape it, and its lifelong health effects.7 Although limited in their size and scope, a number of
studies have established associations between intestinal
microbiome profiles in infants, delivery mode, and / or breast milk exposure.8 - 15 These factors both have long - term health consequences.
In a previous
study of 24 healthy women, vaginal
microbiome composition became less diverse between the second and third trimesters of pregnancy and just before delivery was enriched with Lactobacillus species, likely contributing to vertical transmission of these bacteria during vaginal birth.21 In a
study of 10 newborns in Venezuela, within hours of delivery, the intestinal tracts of infants born vaginally were colonized by Lactobacillus and Prevotella, whereas infants delivered operatively acquired bacteria present on the mother's skin and the hospital environment, such as Staphylococcus, Proprionibacterium, and Corynebacterium.15 Quiz Ref ID Our findings, based on a large group of 6 - week - old infants, indicated that Lactobacillus also contributes to the microbial environment of the
gut but to a lesser extent than Bifidobacteria, Bacteroides, and Streptococcus.
Oligosaccharides in breast milk are thought to promote Bifidobacterium growth, 35 and decreased Bifidobacterium in infancy has been found to be associated with an increased risk for being overweight at age 10 years.36 Many formulas are supplemented with prebiotics such as short - chain galacto - oligosaccharides and long - chain fructo - oligosaccharides that increase the overall representation of Bifidobacterium in the
microbiome of formula - fed infants, and similar to breast milk, promote lactate and short - chain fatty acid prevalence in the infant
gut (reviewed in the
study by Oozeer et al37).
A research
study released in May, 2017 found that the bacteria found in mother's milk and areolar skin seed the infant
gut and profoundly influence the development of infant
microbiome.
«The
study advances our understanding of how the
gut microbiome develops early in life,» Thompson said, «which is clearly a really important time period for a person's current and future health.»
Although the vast majority of research on the
gut microbiome has focused on bacteria in the large intestine, a new
study — one of a few to concentrate on microbes in the upper gastrointestinal tract — shows how the typical calorie - dense western diet can induce expansion of microbes that promote the digestion and absorption of high - fat foods.
«Microbial dispersal impacts animal
guts:
Study with zebrafish finds that transmitted microbes will lead to similar
microbiomes and a selection process for some microbes.»
Dr Luis Pedro Coelho, corresponding author of the
study, commented: «We found many similarities between the gene content of the human and dog
gut microbiomes.
«Cultural revolution in the
study of the
gut microbiome: Human
gut - on - a-chip technology used to co-culture
gut microbiome, human intestinal cells could lead to new therapies for inflammatory bowel diseases.»
Published last week in Cell, a
study by Santamaria and Kathy McCoy, PhD, from the University of Calgary's Cumming School of Medicine (CSM) reveals a new mechanism in the
gut microbiome that regulates pro- and anti-inflammatory cells.
That's the tantalizing finding from a new
study published today that reveals a way that mice — and potentially humans — can control the makeup and behavior of their
gut microbiome.
Through projects at Duke Health, DCRI and the Duke Center for Childhood Obesity Research, Armstrong and other Duke scientists are assessing the most effective strategies to reduce obesity in children, including programs that offer at - risk children access to free medical care, partnerships with municipal recreation programs across North Carolina, and even
studying children's
gut bacteria to determine how the
gut microbiome is related to weight.
In a related
study also published today in PNAS, immunologists led by Gurumoorthy Krishnamoorthy and Hartmut Wekerle of the Max Planck Institute of Neurobiology in Martinsried, Germany, examined the
gut microbiomes of 34 sets of identical twins, aged 21 to 63, in which only one twin had MS.. They found that Akkermansia was slightly but significantly more abundant in MS patients than in their healthy twins.
Changes in the composition and activity of the
gut microbiome in early life can influence the immune system and these changes might indirectly lead to changes in asthma later in life,» said Dr. Anke Maitland - van der Zee, senior author of the
study.
«Several
studies have detected differences in the composition of the
gut microbiome between healthy people and those with obesity and type 2 diabetes, but the cause and effect remain unclear,» says Mark McCarthy, and continues:
Building on the information from this
study, our ultimate long - term goal is to develop a way to alter the
gut microbiome so that it protects people from reinfection.»
A new
study from researchers at the University of Alabama at Birmingham shows that Parkinson's disease, and medications to treat Parkinson's, have distinct effects on the composition of the trillions of bacteria that make up the
gut microbiome.
«Our
study showed major disruption of the normal
microbiome ¬ — the organisms in the
gut — in individuals with Parkinson's,» said Haydeh Payami, Ph.D., professor in the Department of Neurology, in the UAB School of Medicine.
«We investigated more specifically the role of
gut microbiome in the health impact upon lead exposure in this
study,» Xi said.
«The intestinal bacteria, or «
gut microbiome,» you develop at a very young age, can have a big impact on your health for the rest of your life,» said the
study's lead author Dan Knights, a University of Minnesota assistant professor in the Department of Computer Science and Engineering and the Biotechnology Institute.
The
study indicated that Parkinson's is accompanied by imbalance in the
gut microbiome.
It's currently a challenge to do this kind of microbial redesign — antibiotics reduce microbial burden but fail to induce major changes in bacterial composition, and from fecal transplant
studies in the
gut we know that bacterial populations return to a baseline population even after a major shift — so more work is needed to attempt a durable change in the vaginal
microbiome.
Mice in the
study that were put on a rich diet and received
microbiome transplants helped the Wisconsin team expose functional differences attributable to two different transplanted
microbiomes, including a link between the
gut microbiome and insulin secretion.
«Most
studies looking at benefits from soluble corn fiber are trying to solve digestion problems, and we are the first to determine that this relationship of feeding certain kind of fiber can alter the
gut microbiome in ways that can enhance health,» Weaver said.
A new University of Iowa
study in mice shows that drug - induced changes to the
gut microbiome can cause obesity by reducing the resting metabolic rate — the calories burned while sleeping or resting.
Both
studies demonstrate that the composition of the
gut microbiome — the swarms of microorganisms naturally dwelling in the intestines — determines how effective these cancer immunotherapies are.
A new
study describes research helping tease out the mechanics of how the
gut microbiome communicates with the cells of its host to switch genes on and off.
A renaissance man of the
microbiome, his lab
studies the
gut bacteria of everything from cows to sloths to pandas.
Now, new
studies suggest the
gut microbiome plays a critical role in infant growth — sometimes promoting it even in the absence of sufficient calories — providing tantalizing, if preliminary, clues about possible new interventions.
«Greater diversity of bacteria in the
gut microbiome is associated with both a higher response rate to treatment and longer progression - free survival,» said
study leader Jennifer Wargo, M.D., associate professor of Surgical Oncology at MD Anderson.
«We established a link between one bacterial species — Lactobacillus reuteri — that is a normal part of the
gut microbiome, and the development of a population of cells that promote tolerance,» said Marco Colonna, MD, the Robert Rock Belliveau MD Professor of Pathology and the
study's senior author.
«Women with polycystic ovary syndrome have less bacterial diversity in
gut:
Study finds elevated testosterone levels in women linked to changes in
microbiome composition.»
In recent years, the
study of human biology has been shaken up by discoveries of how the bacteria that live in the
gut, the so - called
microbiome, affect metabolism, the immune system, and disease progression.
Reducing this
gut - associated inflammation has been a goal of clinicians and researchers, and rebalancing the
gut microbiome has shown promise in small - animal
studies.
«Twin
study finds that
gut microbiomes run in families.»
The investigators analyzed the
gut microbiomes of 1,126 pairs of twins who were part of the TwinsUK
Study.
«We set out to find out about human genes that are implicated in the regulation of the
gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the
study's senior author.