Citation: V. Braniste, M. Al - Asmakh, C. Kowal, F. Anuar, A. Abbaspour, M. Tóth, A. Korecka, N. Bakocevic, N. L. Guan, P. Kundu, B. Gulyás, C. Halldin, K. Hultenby, H. Nilsson, H. Hebert, B. T. Volpe, B. Diamond, S. Pettersson,
The gut microbiota influences blood - brain barrier permeability in mice.
The gut microbiota influences blood - brain barrier permeability in mice.
«
Gut microbiota influences blood - brain barrier permeability.»
«Remarkably, our findings suggest that composition of
the gut microbiota influence and alter central carbon metabolism in a genotype independent manner.
Not exact matches
In the most recent of these reports (in the latest issue of Science), Dr. Jennifer Wargo, a surgeon and research scientist at M.D. Anderson, along with several dozen colleagues at other institutions, reveal that the composition of a patient's
gut microbiota can significantly
influence whether he or she responds to an immune checkpoint inhibitor — the type of cancer immunotherapy that releases the emergency brakes in the car analogy above.
However, it seems likely that changes in our
gut microbiota and their metabolic products are important in explaining the
influence of diet on many aspects of health, says Harry Flint at the University of Aberdeen, UK.
Maternal secretor status is likely only one of the many factors that
influence the infant
gut microbiota, Lewis said.
The goal of the study was to explore whether fecal
microbiota from human IBS patients with diarrhea has the ability to
influence gut and brain function in recipient mice.
Interestingly, the authors noted that since the study showed that
microbiota in the
gut can
influence the brain, it «adds to evidence suggesting that the intestinal
microbiota may play some role in the spectrum of brain disorders ranging from mood or anxiety to other problems that may include autism, Parkinson's disease and multiple sclerosis.»
Babies are born without bacteria in the
gut, and so it is interesting to identify the
influence dietary factors have on
gut microbiota development in children's first three years of life,» research manager at the National Food Institute Tine Rask Licht says.
Until recently, little was known about how the
microbiota influences the nervous system; however, it is becoming increasingly clear that
gut microorganisms can
influence the brain and behavior.
For example, they aim to investigate whether
gut microbiota composition would be differently
influenced by COX - 1 - or COX -2-specific inhibition, given that COX - 2 inhibitors show less gastrointestinal complications.
Given that the investigators have previously shown the
influence of the host molecular clock on the
gut microbiota, they will also ask if taking this NSAID at different times of day might lead to higher efficacy and less side effects in animal models and eventually in humans.
Review:
Influence of Altered
Gut Microbiota Composition on Aging and Aging - Related Diseases — Jeonghyun Choi — Journal of Lifestyle Medicine
Loss of microRNA - 21
Influences the
Gut Microbiota Causing Reduced Susceptibility in a Murine Model of Colitis — Daniel G W Johnston — Journal of Crohn's and Colitis
Prenatal and postnatal antibiotic exposure
influences the
gut microbiota of preterm infants in neonatal intensive care units — Zhi - Hui Zou — Annals of Clinical Microbiology and Antimicrobials
We will review recent data showing how fiber differences between GB diets and purified diets can significantly
influence gut health and
microbiota, which itself can affect metabolic disease development.
Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human
gut microbiota analysis — Jocelyn Sietsma Penington — Scientific Reports
The composition of the
gut microbiota has been shown to
influence both local and systemic immune responses.
The
gut microbiota can modulate the severity of cerebral ischemic injury through regulatory
influences on IL - 17 — producing...
The link between diet and depression is complex, involving several biological pathways and processes, each of which is «under the
influence of our
gut microbiota,» says Jacka, the study's lead author.
«Your diet directly
influences your
microbiota, and from there it may
influence the status of your
gut's mucus layer and tendency toward disease.
Diet has recently been shown to strongly and rapidly
influence the composition of the
gut microbiota» [4].
Hence, a lot of necessary neurotransmitters in the body are generated by the
gut microbiota, exerting
influence on the human body including the brain, among which many neurotransmitters in the human
gut microbiota are also critical molecules.»
Recent evidence suggests that prebiotics, including fructans and GOSs, modulate brain function by modifying the
gut microbiota, decreasing low - grade inflammation, and / or
influencing the production of neurochemicals (5, 6).
Within the study, there was no evidence of a change in
gut microbiota profile via consumption of the fermented product; however, more importantly, the fermentation of milk significantly alters bioactive peptides and other chemicals that are well capable of
influencing central nervous system function [107 — 110].
Rifaximin may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to its ability to act on IBS pathogenesis, through the
influence on
gut microbiota.
However, the findings that (non-dairy) fermented foods and herbs can have a positive
influence on the intestinal
microbiota are important in that there may be an
influence on longer - term
gut - brain communication.
(25, 26) The altered
gut microbiota may promote insulin resistance, thus
influencing the course of these diseases.
Others, such as those listed below, are modifiable and
influenced by the
gut microbiota.
The availability of tryptophan is heavily
influenced by the
gut microbiota.
GF mice have been shown to have increased plasma tryptophan concentrations, 47, 48 which can be normalized following post-weaning colonization.47 Resident
gut bacteria can utilize tryptophan for growth229 and in some cases, production of indole, 230, 231 or serotonin (reviewed by O'Mahony and colleagues95), while the
microbiota might also affect tryptophan availability by
influencing host enzymes responsible for its degradation.47 By limiting the availability of tryptophan for serotonin production in the CNS (EC - derived serotonin does not cross the BBB), the
gut microbiota could
influence serotonergic neurotransmission.95 In vulnerable populations, reducing the circulating concentrations of tryptophan has been shown to affect mood, and to reinstate depressive symptoms in patients who have successfully responded to selective serotonin reuptake inhibitors.232, 233 The
gut microbiota could also
influence the production of both neuroprotective and neurotoxic components of the kynurenine pathway.224
The tantalizing links between
gut microbes and the brain: Neuroscientists are probing the idea that intestinal
microbiota might
influence brain development and behaviour.
«This could manifest, behaviorally, via magnified antioxidant and anti-inflammatory activity, reduction of intestinal permeability and the detrimental effects of LPS, improved glycemic control, positive
influence on nutritional status (and therefore neurotransmission and neuropeptide production), direct production of GABA, and other bioactive chemicals, as well as a direct role in
gut - to - brain communication via a beneficial shift in the intestinal
microbiota itself.»
But unlike other organs like the liver and brain, which are hardwired to function according to predefined genetic codes, the makeup and function of the
gut microbiota is heavily
influenced by environmental stimuli — especially nutrition.
Even bone formation, changes in moods, and sleeping behavior are
influenced by the
gut microbiota
In my previous article, I described how each of us possesses a
gut microbiota with a unique population of microbes and that our uniqueness may
influence the efficacy of the probiotic supplements that we use.