Not exact matches
Highly pathogenic
avian influenza (HPAI)
H5 viruses of Eurasian origin continue to circulate and evolve in North American wild birds.
In additional experiments, the scientists found that participants who had significant antibody responses did not necessarily also have significant immune system T cell responses to
avian viruses, indicating that these two arms of immunity can be independently boosted after vaccination or infection; that individuals who reported receiving seasonal
influenza vaccination had significantly higher antibodies to the
avian H4,
H5, H6, and H8 subtypes; and that participants with exposure to poultry had significantly higher antibody responses to the H7 subtype, but to none of the other subtypes tested.
They exposed plasma from the samples to purified proteins of
avian influenza virus H3, H4,
H5, H6, H7, H8 and H12 subtypes using two laboratory tests to see how many different
viruses participants reacted to, and how strongly.
The extracellular domain of the
H5 or H7 protein of the respective
avian influenza viruses was transplanted into the Newcastle disease
virus vaccine strain LaSota in order to make the vaccine constructs.
The gene, called
H5, is one of 16 subtypes of hemagglutinin, a protein that binds the
avian influenza virus to the cells it infects.