Yet pigs are a likely source of a human pandemic H5N1 virus because they are susceptible to both human and
avian viruses, creating opportunities for genetic reassortment in co-infected animals.
The paper explains that this novel H1N1 has two genes from
an avian virus that entered Eurasian swine in 1979, three from the old - fashioned H1N1 in North American swine, two genes from the triple reassortants in North American swine, and the final one from humans transmitted to us from birds in 1968.
But in 1998, researchers discovered that this rock - steady swine H1N1 had combined with a human H3N2 and an American
avian virus.
So far, the killer virus looks like a run - of - the - mill swine flu, not
an avian virus as some virologists had suspected — leaving scientists to wonder why the strain was so deadly.
The more humans that
an avian virus infects, Stöhr says, the greater the risk that it will morph into a flu pandemic.
Kawaoka, in contrast, stitched the hemagglutinin gene from
the avian virus — the H5 — into a H1N1 virus that easily spreads between humans and caused the relatively mild 2009 pandemic.
* Update, 13 July, 10:26 a.m.: The item was updated to clarify that H5N1 is
an avian virus and to correct a typographic error.
In additional experiments, the scientists found that participants who had significant antibody responses did not necessarily also have significant immune system T cell responses to
avian viruses, indicating that these two arms of immunity can be independently boosted after vaccination or infection; that individuals who reported receiving seasonal influenza vaccination had significantly higher antibodies to the avian H4, H5, H6, and H8 subtypes; and that participants with exposure to poultry had significantly higher antibody responses to the H7 subtype, but to none of the other subtypes tested.
New strains arising from such mixing have the potential to infect humans and spark a pandemic, so information about swine susceptibility to H7N9 could help scientists gauge the pandemic potential of
the avian virus.
They also identify factors that may be involved in duck host immune response to
avian virus infection, including the avian and mammalian - defensin gene families.
The accusation that Capua and others set off a human epidemic made no sense, she said, because one mild flu case does not constitute an epidemic; moreover,
the avian virus she allegedly spread was a different strain than the one that killed the birds in Italy.
Avian viruses prefer α 2,3 galactose receptors, which are common in birds but were thought to be nearly absent in humans.
For folks concerned that this is the next bird flu, it's not worth the alarm, as the virus responsible for avian flu is much more serious, compared to the bacterial psittacosis (Also, it's worth noting that the H7N9
avian virus has not been detected in the United States — neither in humans nor birds.)
Avian (bird) flu is caused by influenza
A avian viruses that occur naturally among birds.
How, then, did SV40 get through; how did
the avian virus get into the MMR vaccine; how did parvovirus slip through the net; and how did AIDS suddenly arrive from nowhere?
Not exact matches
Poultry products exported by the Atlanta - based company are also challenged as a result of the
avian influenza
virus, which has led to many countries worldwide to close their doors to poultry imports altogether.
The combined pressures of climate change and epidemics sweeping through intensive animal agriculture such as H5N2
avian flu and porcine epidemic diarrhea
virus (PEDV) are growing challenges for industrial agriculture, and workers organizing to demand fair pay and conditions combined with increasing consumer pressure for greater transparency and better treatment of land, animals, and workers, are having an effect.
It is feared that if the
avian influenza
virus combines with a human influenza
virus (in a bird or a human), the new subtype created could be both highly contagious and highly lethal in humans.
Today infectious disease experts recognize that an
avian flu
virus could genetically change enough to trigger a human pandemic.
In February 2004,
avian influenza
virus was detected in birds in Vietnam, increasing fears of the emergence of new variant strains.
(These proteins serve as the basis for influenza nomenclature; for instance, the H5N1
virus refers to specific classes of hemagglutinin and neuraminidase, which in this example correspond to an
avian flu subtype.)
Viruses like
avian flu or the animal coronavirus that mutated into SARS must be relatively benign in their original hosts to spread from one animal in the wild to the next.
Although
avian flu made few headlines in 2007, the
virus continued to claim lives in Asia, particularly in Indonesia.
Epidemiologists have worried that the
avian flu
virus, formally known as H5N1, could mutate enough to sicken and pass among humans, who would not have an immunity to it.
As controversy rages around the scientists who created mutant strains of the H5N1
avian influenza
virus, leading flu researchers have called for a 60 - day voluntary pause on such work.
The H7N9
avian influenza
virus was first reported in humans in March 2013 in China.
An international team of influenza researchers in China, the United Kingdom and the United States has used genetic sequencing to trace the source and evolution of the
avian H7N9 influenza
virus that emerged in humans in China earlier this year.
Before SARS, before worries about widespread
avian flu, the Nipah
virus infected humans with surprising ease.
So while
avian flu continues to make headlines, Nipah is also a
virus to watch.
As a result, no one can explain why the
avian H5N1 flu
virus has infected some 400 people worldwide, mainly in Asia and Africa, but failed so far to adapt completely to humans.
Since Chinese officials confirmed March 29 that three people had contracted H7N9
avian influenza, the
virus has sickened 43 people.
Why would scientists deliberately create a form of the H5N1
avian influenza
virus that is probably highly transmissible in humans?
A laboratory test showing airborne transmission of the H7N9
avian influenza
virus between the animals has raised fears that the
virus is poised to become a human pandemic.
The 2009 strain of H1N1 is, in fact, a hodgepodge of swine, human and
avian strains of the
virus.
Pigs have multiple influenza receptors and can harbor human and
avian strains of the
virus in addition to their own, leading to reassortment.
Researchers quickly discovered that the
virus was a type of
avian influenza, known as H7N9, never before seen in humans.
Michael Osterholm, director of the University of Minnesota's Center for Infectious Disease Research and Policy in Minneapolis, points out that the 2004 document was based on input from an international panel of 22 scientists and public - health officials, in response to the threat of the deadly H5N1
avian flu
virus.
The current H5N1 strain is a fast - mutating, highly pathogenic
avian influenza
virus (HPAI) found in multiple bird species.
In March 2013 the first human infections with the
avian influenza A (H7N9)
virus were reported in China, and since that time hundreds of cases have been documented.
A new version of the H7N9
avian influenza
virus might be able to cause widespread infection and should be closely monitored, scientists say, although it currently doesn't spread easily between people.
Chairul Nidom of Airlangga University in Surabaya, Indonesia, and colleagues in Japan, have been tracking H5N1 in pigs since 2005 in Indonesia, the country hardest hit by the
avian flu
virus.
A triple reassortment strain of an H1N2
virus, with genes from
avian, swine and human flu, has been shown to jump easily via air to mammals
Ebright: Future work with lab - generated transmissible
avian influenza
viruses should be performed only at the highest biosafety level, only at the highest biosecurity standard, and only after approval by, and under the oversight of, a national or international review process that identifies risks and benefits, weighs risks and benefits, mitigates risks, and manages risks.
Avian H5N1
viruses do not transmit among mammals, and therefore such experiments provide invaluable insight into this process.
The H5N1
avian influenza strain developed strong resistance to oseltamivir, better known as Tamiflu, in two Vietnamese patients who died from the
virus early this year, according to a new study.
One of the top science stories of 2012 involved a furore about the wisdom of enhancing the transmissibility of the H5N1
avian influenza
virus in ferrets.
A new study has found that a novel
avian - origin H7N9 influenza A
virus, which has recently emerged in humans, attaches moderately or abundantly to the epithelium of both the upper and lower respiratory tracts.
«These characteristics fit with increased virulence of these emerging
avian H7
viruses compared to that of human influenza
viruses,» says Dr. Kuiken.
It turns out that all 20th - century pandemic
viruses, among them the 2009 swine flu, have
avian flu PB1 genes.
Using
virus histochemical analysis, the investigators looked at the pattern of attachment of two genetically engineered emerging H7
viruses (containing the hemagglutinin (HA) of either influenza
virus A / Shanghai / 1 / 13 or A / Anhui / 1 / 13) to fixed human respiratory tract tissues and compared the findings to attachment patterns seen with human influenza
viruses with high transmissibility but low virulence (seasonal H3N2 and pandemic H1N1) and highly pathogenic
avian influenza (HPAI)
viruses with low transmissibility and high virulence (H5N1 and H7N7).