Sentences with phrase «hct116 colon cancer cell line»

The study builds on previous findings suggesting that AIM2 limits cancer cell growth in colon cancer cell lines, Wilson said, as well as on a clinical report of poor prognosis in colon cancer patients with low or missing AIM2 levels.

So far, Menendez and his colleagues have discovered the fatty acid cuts the expression of the gene in ovarian, stomach, and colon cancer cell lines.

In the current studies, the researchers used a transplanted colon cancer cell line.

For the time course study, cells were treated with 20 μM of EGCG for 12, 24, 48, 72, or 144 h. Human colon cancer cell line HT - 29 and prostate cancer cell line PC3 were obtained from American Type Culture Collection (Manassas, VA), and were grown in McCoy's 5A and RPMI 1640 containing 10 % fetal bovine serum, respectively.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

In the present work, our observations led us to conclude that inhibition of TRF2 abrogates the formation and maintenance of the spheroidal phenotype and loss of TRF2 results in down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell line.

Furthermore, using a phospho - tyrosine [Y] 474 (in - house generated) and a phospho - serine [S] 176 (Cell Signaling, Inc., Danvers, MA) RIPK2 antibodies, we confirmed that active RIPK2 is recognized by these antibodies upon activation with MDP treatment in 293HEK fibroblast and HCT116 colon cancer epithelial cells (Fig. 3E, left panel) and detection of constitutively active RIPK2 in the colon cancer cell line SW480 (Fig. 3E, right panel).

HCT116 and DLD - 1 are colon cancer cell lines, whereas RAT - 1 and MODEK are normal rat and mouse intestinal cell lines, respectively.

Editing GalNAc - T6 out of a colon cancer cell line changed its growth form to one more closely resembling healthy colon tissue.

(Source) Another study evaluated the effects of avocado on gastrointestinal cancers, and found avocado extract to inhibit the growth of esophageal squamous cell and colon cancer cell lines.

Scientists studied the effect of GSE on various stages of colon cancer cell lines, ranging from Stage 1 to Stage IV.

Not exact matches

The cell lines were actually lung, colon and stomach cancers.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

Mice lack colonic BMI - 1 stem cells that play a critical role in how colon cancer forms — or carcinogenesis — and how material passes through the cell lining of the intestinal wall — or gut permeability.

The membrane is coated with proteins that support 3 - D cell growth and it's seeded with human intestinal epithelial cells (from a cell line originally isolated from a colon cancer).

HuH - 7 (human HCC), HepG2 (human hepatocellular blastoma), 293T (human embryonic kidney fibroblast), HeLa (human cervical cancer cells), NIH 3T3 (murine fibroblast), and HCT116 (human colon cancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MDcancer cells), NIH 3T3 (murine fibroblast), and HCT116 (human colon cancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MDcancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MDCancer Center of the Johns Hopkins University School of Medicine, Baltimore, MD; ref.

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation.14 This explains the fact that in industrialized countries, where there are many carcinogens in the diet and where consumption of vegetable oils and carcinogens is high, some studies have correlated meat - eating with colon cancer; but in traditional societies, where vegetable oils are absent and the food is free of additives, meat - eating is not associated with caColon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation.14 This explains the fact that in industrialized countries, where there are many carcinogens in the diet and where consumption of vegetable oils and carcinogens is high, some studies have correlated meat - eating with colon cancer; but in traditional societies, where vegetable oils are absent and the food is free of additives, meat - eating is not associated with cacolon, leading to tumor formation.14 This explains the fact that in industrialized countries, where there are many carcinogens in the diet and where consumption of vegetable oils and carcinogens is high, some studies have correlated meat - eating with colon cancer; but in traditional societies, where vegetable oils are absent and the food is free of additives, meat - eating is not associated with cacolon cancer; but in traditional societies, where vegetable oils are absent and the food is free of additives, meat - eating is not associated with cancer.

As we mentioned above, the fiber in brown rice can also help to protect you against colon cancer since fiber binds to cancer - causing chemicals, keeping them away from the cells lining the colon, plus it can help normalize bowel function, reducing constipation.

Red foods like red bell peppers and tomatoes contain a phytochemical called lycopene, which may have an anti-inflammatory affect on the cells lining the heart and blood vessels, and may reduce the risk of developing prostate cancer among other cancers such as breast, lung, bladder, ovarian, and colon.

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis adcolon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis adColon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis adcolon, leading to tumor formation» [Emphasis added].

In addition, it was discovered that the impact of red raspberry on pro-apoptotic is very strong against cell line which have been examined for colon cancer.