He noticed that
the HD mice he studies show a lack of motivation.
Not exact matches
Mice transplanted with cells grown from a patient suffering from Huntington's disease (
HD) develop the clinical features and brain pathology of that patient, suggests a
study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.
Studies in
mouse models of
HD showed that creatine raises brain ATP levels and protects against neurodegeneration.
A recent
mouse study of a drug known as CTEP suggests the drug is surprisingly helpful for
HD - like symptoms in
mice.
But these
mice are a very useful tool for
studying changes in the brain that happen in
HD.
They're
studying it using
mice with the mutant
HD gene, called BAC -
HD mice.
By comparing short - and long - term treatment with CTEP in
HD mice, Ferguson's team was able to
study this question very closely.
Some of these greasy molecules are reduced in
HD, and a new
study demonstrates that replacing one specific type, called ganglioside GM1, leads to dramatic improvements in the behavior of
HD mice.
Today, scientists can
study HD using «model»
mice, flies, sheep, and other animals.
And in animal
studies using
mice with
HD, research has shown that «environmental enrichment» - giving the
mice more stimulating surroundings - delays the onset and slows the progression of the disease.
These
mouse studies highlight how careful we have to be with drugs for
HD.
He is using cutting edge microscopes and techniques to
study individual connections - synapses - between neurons in
HD mice.