Sentences with phrase «hep cells express»

Furthermore, enhanced hiPS - HEP cells express high levels of the LDL receptor (Figure 5, Panel B) and take up fluorescently labeled LDL (Figure 5, Panel A).

Additionally, the enhanced hiPS - HEP cells express genes involved in the urea cycle within the same range as hphep cells, and the cells secrete albumin and urea.

The enhanced hiPS - HEP cells express PCSK9 and other genes that regulate blood cholesterol levels, as well as principal genes involved in uptake, synthesis, and beta - oxidation of fatty acids.

Not exact matches

The enhanced hiPS - HEP cells respond to insulin with phosphorylation of protein kinase B - α (Akt), even at low insulin concentrations, and the genes involved in glycogen metabolism, gluconeogenesis, and insulin signaling are expressed at similar levels as in hphep cells.

Albumin and α1AT are well - expressed in enhanced hiPS - HEP cells from all three hiPS cell lines (Figure 3, Panels A, B, and C), as shown by immunostaining and mRNA expression analysis.

Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.

In our experiments, both HNF4α and ASGPR1 are well - expressed in enhanced hiPS - HEP cells from all three hiPS cell lines (Figure 2), as shown by homogeneous nuclear staining for HNF4α and homogeneous membrane staining for ASGPR1.

Here, we show that enhanced hiPS - HEP cells respond to insulin with phosphorylation of protein kinase B - α (Akt), even at low insulin concentrations (Figure 4, Panels E and F), and that the genes involved in glycogen metabolism, gluconeogenesis, and insulin signaling are expressed at similar levels as in hphep cells (Figure 4, Panels B, C, and D).