Sentences with phrase «hiv immunogen»
The researchers injected the four cows with an HIV immunogen, a molecule that can prompt the HIV immune response.
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Using the findings from this study, the team has designed vaccine immunogens to selectively trigger the cooperating antibody - producing B cells to cooperate to make broadly neutralizing antibodies in a manner that mimics broadly neutralizing antibody development in natural HIV infection.
Immunogens are designed to elicit the production of highly coveted broadly neutralizing antibodies that protect against HIV - 1 [Also see Report by McGuire et al..]
A major goal of HIV - 1 vaccine development is to identify immunogens capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating, neutralization - resistant (tier 2) viruses.
A critical implication of this work for the field of HIV vaccine design is the observation that the most potent and broad individual anti-HIV VHH, J3, was elicited in response to the gp140 immunogens used.
Dr. Schief's work focuses on computation - guided and structure - based design of immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and other pathogens that have frustrated traditional vaccine design strategies.
«Although cows are not humans, these data provide important insights on how the immune system responds to HIV [immunogens],» Barouchs did not take part in the research.
The first immunogens are those similar to the trimer outer Envelope protein of native HIV.
Researchers are making progress in developing vaccine immunogens designed to induce broadly neutralizing antibodies (bNAbs) against HIV.