«Because SEVI can so greatly enhance
HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness,» Greene explained.
We have successfully evolved families of aptamers targeting the HIV envelope that neutralize
HIV infectivity, yet can be internalized in HIV infected cells to deliver therapeutic siRNAs.
Not exact matches
The lower
infectivity of
HIV - 2 compared to
HIV - 1 implies that fewer of those exposed to
HIV - 2 will be infected per exposure.»
In collaboration with many researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of influenza; the impact of behavioral changes, long periods of infectiousness, variable
infectivity, co-infections, prostitution, social networks, and vaccine efficacy on
HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales for epidemics of foot and mouth disease.
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration of
infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e5.2 SUBTYPE: B This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpri
Env clones with inserts in the correct orientation screened for
infectivity by co-transfection with an env deficient
HIV - 1 (SG3env) backbone in 293T cells
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e4.9 Full - length genome: SUBTYPE F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccin
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e5.4 SUBTYPE: BF1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr
Syncytium inducing phenotype (MT2): NSI Coreceptor use: CCR5 Titration of
infectivity (TCID50 / ml): 10e4.6 Full - length genome: C This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbi
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e6.2 SUBTYPE: F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Ent
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e4.2 Full - length genome: SUBTYPE F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccine
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e6.4 Full - length genome: SUBTYPE B This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines a
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e6.8 SUBTYPE: BG (URF) This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbici
Env clones with inserts in the correct orientation screened for
infectivity by cotransfection with an env deficient
HIV - 1 (SG3env) backbone in 293T cells
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e6.8 SUBTYPE: BF (URF) This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbici
Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of
infectivity (TCID50 / ml): 10e5.2 SUBTYPE: F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr
Syncytium inducing phenotype (MT2): NSI Coreceptor use: CCR5, CXCR4: R5 Titration of
infectivity (TCID50 / ml): 10e5.6 Full - length genome: SUBTYPE F1 This isolate is part of an European Panel of
HIV - 1 isolates form the Network of Excellence Euro
A different viral envelope protein (Env), usually from VSV - G due to wide
infectivity, is often used as a substitute for
HIV - 1 Env, which can only infect CD4 + cells.
SAN FRANCISCO, CA — Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have discovered a new agent that might inhibit the
infectivity of
HIV.
The newly identified site can be attacked by human antibodies in a way that neutralizes the
infectivity of a wide variety of
HIV strains.
The scientists determined that the two broadest neutralizers among these antibodies, PGT151 and PGT152, could block the
infectivity of about two - thirds of a large panel of
HIV strains found in patients worldwide.
The serum from a small set of the samples indeed turned out to block the
infectivity, in test cells, of a wide range of
HIV isolates, suggesting the presence of broadly neutralizing antibodies.