Sentences with phrase «hiv microbicide»

«Because SEVI can so greatly enhance HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness,» Greene explained.

Not exact matches

A series of vaccine and microbicide clinical trials to prevent HIV transmission have been unsuccessful, and scientists are returning to the drawing board to devise new approaches.

As reported online this week in Science and in a presentation at the 18th International AIDS Conference in Vienna, of the 444 women who received a placebo gel, 60 became infected with HIV versus 38 infections in the 445 women who received the microbicide.

Another application could be their development into crèmes or gels (i.e. microbicides) that prevent transmission of viruses like HIV during sexual intercourse.

The largest study ever conducted of a microbicide designed to prevent HIV infection has resulted in yet another case of high hopes being dashed about a promising product.

McCormack says the data mark the end of the road not just for this vaginal gel but the whole class of microbicides that use nonspecific compounds to prevent HIV - infection.

When the gel comes in contact with semen, the change in pH causes it to reliquefy and release an HIV - killing microbicide.

Where budgets are limited, they suggest money should be allocated first to increasing male circumcision, then to more frequent HIV screening, use of vaginal microbicides and increasing antiretroviral therapy.

These include voluntary male circumcision — now recommended by the World Health Organization and Joint United Nations Programme on HIV / AIDS as a preventive strategy — as well as vaginal microbicides and oral pre-exposure prophylaxis, all of which confer only partial protection against HIV.

Rhesus macaques like this one blocked the monkey version of HIV with a new microbicide.

For 20 years, AIDS researchers have searched for a vaginal microbicide that can block HIV, but they have made little progress.

The failure of first - generation microbicides has led the field to largely abandon the strategy behind them: that HIV could be stopped by compounds, such as soaps, that disable the virus without specifically attacking it.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

His contributions to microbicides for HIV prevention spans two decades and culminated in the CAPRISA 004 tenofovir gel trial which provided proof - of - concept that antiretroviral drugs can prevent sexually transmitted HIV infection and herpes simplex virus type 2 in women.

Among other grants, he has participated to several EC - FP6 funded grants (AVIP, NEAT, Europrise) and coordinated the «GISHEAL» program on the genetics and immunology of HIV long term nonprogressors; he has also participated to the FP7 - funded project «AIM - HIV» on microbicide discovery.

Professor Abdool Karim is a member of the UNAIDS Scientific Expert Panel and Scientific Advisor to the Executive Director of UNAIDS, Scientific Advisory Board member of the US President's Emergency Pan for AIDS Relief (PEPFAR), Chair of the PEPFAR Adolescent Girls and Young Women Expert Working Group, a member of the HIV Centre Strategic Advisory Committee and the NIH OAR Microbicides Planning Group.

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 X4 Titration of infectivity (TCID50 / ml): 10e6.6 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: B This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpri

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.4 SUBTYPE: BF1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e6.2 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Ent

Syncytium inducing phenotype (MT2): NSI Coreceptor use: R5 Titration of infectivity (TCID50 / ml): 10e5.2 SUBTYPE: F1 This isolate is part of an European Panel of HIV - 1 isolates form the Network of Excellence European Vaccines and Microbicides Enterpr

James Eghaghe The New HIV Vaccine and Microbicide Research Advocacy Society of Nigeria (NHVMAS), Nigeria

HIVR4P supports cross-fertilization among research on HIV vaccines, microbicides, PrEP, treatment as prevention, and other biomedical prevention approaches, while also providing a venue to discuss the research findings, questions, and priorities specific to each.

Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.

Dr. Zeda Rosenberg, who leads the International Partnership for Microbicides, argued in Bangkok that a microbicide to protect women from HIV could be available within five years.

Community members and leading and upcoming Ugandan scientists engaged in dialogue on issues surrounding HIV vaccines, microbicides and pre-exposure prophylaxis (PrEP).

We tried to address some of these issues while working on an RNAi - based microbicide to prevent sexual transmission of viral infection (and ultimately HIV) in mice.

Results from an initial study combining a microbicide candidate and experimental vaccine are promising enough to at least keep Imperial College virologist Robin Shattock coming back for more in pursuing what could be a novel move in preventing HIV infection.

The Resource Tracking for HIV Prevention R&D Working Group (RTWG), led by AVAC, in partnership with the International AIDS Vaccine Initiative and UNAIDS tracks trends in R&D investments and expenditures for biomedical HIV prevention options, including AIDS vaccines, microbicides, multipurpose prevention technologies, pre-exposure prophylaxis (PrEP), treatment as prevention, medical male circumcision, female condoms, HSV - 2 vaccines, HIV cure and therapeutic vaccines.

Researchers from the University of Nebraska - Lincoln have generated an «on - off switch» into a weakened form of HIV, potentially creating a new vaccine for Comprehensive exploration of research into HIV prevention, including microbicides, PrEP, PEP, condoms, circumcision and HIV treatment as prevention.

Learn about HIV prevention Comprehensive exploration of research into HIV prevention, including microbicides, PrEP, PEP, condoms, circumcision and HIV treatment as prevention.