Sentences with phrase «hiv vaccine trial»

The HIV vaccine trial in Thailand, which was led by MHRP, was a major focus at the conference.

Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in Thai volunteers.

Immunogenicity of ALVAC - HIV (vCP1521) and AIDSVAX B / E Prime Boost Vaccination in RV144, Thai Phase III HIV Vaccine Trial

The Army - led RV144 HIV vaccine trial provided the first evidence in humans that a safe and effective preventive HIV vaccine is possible.

It played a critical role landmark RV144 «Thai Study,» a 16,000 person study which was the only HIV vaccine trial to date to demonstrate modest (31 %) efficacy of a potential HIV vaccine, and the follow - on studies on the RV144 correlates of risk.

Kyle Rybczyk: HIV vaccine trial clinic coordinator will «never regret being involved in this work» September 19, 2017

Many scientists believe that the Thai HIV vaccine trial, which had recruited over 2,500 of its projected 16,000 participants by June 2004, has no chance of success.4 Yet the investigators overseeing the study (who include American scientists), the local Thai institutional review boards, and the Thai Ministry of Health have all remained silent — at least on the record.

«This finding is consistent with a hypothesis generated out of the follow - up studies to the RV144 HIV vaccine trial in Thailand that showed the first efficacy in humans,» noted COL Nelson Michael, Director of the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research.

She is the Protocol Chair for RV329: African Cohort Study; RV262, an international Phase I DNA / MVA HIV vaccine trial; and for RV398, an upcoming Phase I trial of the VRC01 broadly neutralizing monoclonal antibody administered in acute HIV infection in East Africa and Thailand.

The event included a scientific lecture on Thai HIV vaccine trial (RV 144) and presentations on milestones achieved over the decade (2002 — 2012) in the different programs.

The HIV Vaccine Trial Network (HVTN) plans to conduct clinical trials in heterosexual adults that will evaluate a prime - boost vaccine regimen similar to that used in RV144 adjusted to target the most common subtype of HIV in the region (subtype C).

MHRP's molecular epidemiologists played a key role on a research team that analyzed the HIV - 1 genome sequences from infected volunteers in the Step HIV vaccine trial.

The Step study, an international HIV vaccine trial co-sponsored by the National Institute of Allergy and Infectious Diseases and the pharmaceutical company Merck, was halted in 2007 when the vaccine failed to prevent HIV infection in volunteers or affect the virus load in those infected.

More trials in the offing Sanofi Pasteur announed the P5 (Pox Poretin public private partnership) between US National Institute of Health, Bill and Melinda Gates Foundation, US Military, HIV Vaccine Trial Network (HVTN), Sanofi Pasteur and Novartis Vaccine.

The Network's HIV Vaccine Trial Units are located at leading research institutions in 27 cities on four continents.

The NIH formed its own HIV vaccine trial network in 2000 to oversee clinical research sites in the U.S., Africa, Asia, the Caribbean and South America.

We talk with two pioneering physicians — one of whom is overseeing the world's largest HIV vaccine trial and the other led a groundbreaking successful pilot in the U.S. — to see how far we are from getting to zero.

Dr. Larry Corey, Principal Investigator, HIV Vaccine Trials Network; Past President and Director, Fred Hutchinson Cancer Research Center Dr. Diane Havlir, Professor of Medicine, University of California, San Francisco Moderator: Siobhan O'Connor, Time Magazine

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

«Past HIV vaccine trials reveal new path to success.»

If you decide to participate in an HIV Vaccine Trials Network (HVTN) study, you will be given a copy of this document in one of these languages, depending on your preference.

The world's largest HIV vaccine trials network is headquartered here.

SEATTLE, WA and DURHAM, NC — The HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) today announced the initiation of HVTN 704 / HPTN 085, also known as Antibody Mediated Prevention (AMP) or the AMP Study, a Phase 2b clinical trial to evaluate the safety and efficacy of VRC01, a broadly neutralizing monoclonal antibody (bnAb).

The HIV Vaccine Trials Network (HVTN) is the largest worldwide clinical trials network dedicated to the development and testing of HIV / AIDS vaccines.

An analysis of HIV vaccine trials (mostly ones that use DNA vaccines) showed that women showed better T - cell responses to such vaccines than men, and people with a lower body mass index showed better T - cell responses than people with a higher body mass index.

The trials will be conducted by the publicly funded, Hutch - based HIV Vaccine Trials Network, or HVTN, the largest global network striving to develop vaccines to prevent HIV / AIDS.

MHRP's international research program has six clinical research sites in the U.S., Africa and Asia, where it conducts HIV cohort studies, HIV vaccine trials and therapeutic studies.

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«We are in the midst of an unprecedented time in HIV vaccine research,» said Dr. Larry Corey, who leads the HIV Vaccine Trials Network.

MUWRP was selected by the NIAID to conduct RV 247 based on their expertise in conducting HIV vaccine trials.

Before joining IDRI, Tracey worked as a Protocol Development Manager with the HIV Vaccine Trials Network at the Fred Hutchinson Cancer Research Center where she led multi-disciplinary teams in the design and implementation of clinical trials evaluating candidate HIV and tuberculosis vaccines.

We in the HIV Vaccine Trials Network (HVTN) community owe enormous thanks and gratitude for her support and guidance since the advent of our organization 17 years ago.

Tags: genetics, hiv vaccine trials network, malaria, Malaria, Peter Gilbert, Trevor Bedford, Vaccine and Infectious Disease, VIDD, World Health Organization

Fred Hutch's Dr. Jim Kublin, executive director of HIV Vaccine Trials Network, told MSNBC that Sheen could have carried the virus up to 10 years before it was detected.

Sanjay Gurunathan from Sanofi Pasteur, manufacturer of one of the vaccines used in RV144, said a new partnership of the US National Institute of Allergy and Infectious Diseases, The Bill & Melinda Gates Foundation, HIV Vaccine Trials Network, US Military HIV Research Program (MHRP), and Sanofi Pasteur — known as the Pox Protein Public Private Partnership, or P5 — will aim to increase vaccine efficacy from the 31.2 percent of the RV144 trial to 50 percent.

Dr. Larry Corey speaks at an HIV Vaccine Trials Network conference in Cape Town, South Africa, in October 2013.

At the HIV Vaccine Trials Network (HVTN), we believe that well - informed communities contribute to better science.

National Institute of Allergy and Infectious Diseases (NIAID) NIAID is the primary agency of the US government devoted to research on HIV / AIDS and the sponsor of the HIV Vaccine Trials Network.

Kyle Rybczyk, clinic coordinator for the Nashville unit of the HIV Vaccine Trials Network, first encountered HIV as a nurse in the mid-1980s.

When people with HIV don't take antiretrovirals, they might expect to live for about 6 months, says Larry Corey, MD, a principal investigator for the HIV Vaccine Trials Network at the Fred Hutchinson Cancer Research Center in Seattle.

The National Institute of Allergies and Infectious Diseases selects Fenway as one of eight sites — and the only community - based health center — to recruit patients for the nation's first HIV vaccine trials.

Not exact matches

Researchers at Oregon Health & Science University are currently looking for volunteers that can be tested during an upcoming clinical trial for a vaccine that may cure HIV, the virus that causes AIDS.

Specifically, 74 people who had received the placebo became infected with HIV in the trial period, compared with the 51 people who became infected after receiving the vaccine, which makes for a protective effect of 31.2 percent.

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

After years of false starts, a new generation of DNA vaccines and medicines for HIV, influenza and other stubborn illnesses is now in clinical trials

So say scientists at Merck, who learned from trials in 2007 that their vaccine, based on a live, weakened adenovirus carrying genes for HIV proteins, was ineffective.

The recent phase 2 STEP trial of the HIV vaccine (V520) showed disappointing results, but another vaccine made by GeoVax will be moving into phase 2 clinical trials in the next few months based on promising phase 1 results.

Schlesinger visited him only a week ago with data about an HIV clinical trial of a dendritic cell vaccine, and Steinman was absorbed in what she had to share.

With HIV, progress has been slow, but we have a glimmer of hope now from the so - called RV144 trial in Thailand, in which an experimental HIV vaccine turned out to be about 30 percent effective.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»