Sentences with phrase «ht receptor»

These findings raise the question as to how reduced 5 - HT and TPH2 levels are related to the increased 5 - HT cell density, 11 morphologic 5 - HT neuronal immaturity, 11 reduced 5 - HT transporter binding relative to 5 - HT cell number, 11 and altered 5 - HT receptor binding9 - 11 in the SIDS cases.

The ability of the specific 5 - HT3 antagonist to block Ca2 + responses indicates that 5 - HT3 is the only 5 - HT receptor capable of generating a Ca2 + signal in the ganglion cells.

This serotonin crosses the tiny gap to the nerve ending, where it activates 5 - HT receptors and triggers nerve impulses.

Although other 5 - HT receptors may exist in the ganglion, 5 - HT3 is the only ionotropic 5 - HT receptor and is normally involved in excitatory signaling in the nervous system (Galligan et al., 2000; Galligan, 2002).

In addition, we tested whether other 5 - HT receptors were upregulated after genetic deletion of 5 - HT3 by measuring 5 - HT responses in isolated geniculate ganglion neurons of WT and 5 - HT3AKO mice.

Not exact matches

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

Next, to test whether the response to 5 - HT was specific to 5 - HT3 receptors, we blocked 5 - HT3 receptors with ODS and coapplied 5 - HT.

In the present study, we have investigated the role of 5 - HT in the communication between taste receptor cells and afferent nerve fibers.

Our physiological analysis established that functional 5 - HT3 receptors are present only in these GFP - labeled ganglion cells and that 5 - HT3 is required for ganglion cell responses to 5 - HT.

The 5 - HT released by type III cells could also activate 5 - HT3 receptors on afferent nerve fibers.

5 - HT released by type III taste cells activates adjacent type II taste cells that express the 5 - HT1A receptor, resulting in inhibition of type II cells (Herness and Chen, 2000; Huang et al., 2005; Jaber et al., 2014).

Nonetheless, some of the released 5 - HT will likely activate the neural 5 - HT3 receptors.

Herein, we test whether 5 - HT released by taste cells plays a role in the transmission of taste information by activation of 5 - HT3 receptors on afferent nerve fibers.

Grailhe, R.; Waeber, C.; Dulawa, S. C.; Hornung, J. P.; Zhuang, X.; Brunner, D.; Geyer, M. A.; Hen, R. Increased exploratory activity and altered response to LSD in mice lacking the 5 - HT (5A) receptor.

Using a 2 - mm micropunch (Harris Uni-core; EMS, Hatfield, Pennsylvania), tissue was collected from 2 major components of the medullary 5 - HT system, the raphé obscurus and paragigantocellularis lateralis (PGCL), according to the atlas of Paxinos and Huang, 19 and standardized protein samples were obtained for Western blot analysis in each SIDS case and control.20 Twenty - micrometer tissue sections were collected from the remaining blocks in a standardized manner for tissue receptor autoradiography.

Serotonin (5 - HT) 2C receptors play an important role in the modulation of monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion, and alterations in their functional

Second, in components of the medullary 5 - HT system that contain 5 - HT cell bodies (ie, PGCL, gigantocellularis, and intermediate reticular zone), there was a significant age × diagnosis interaction with decreased receptor binding with increasing age in SIDS cases but no change in controls (Figure 2A).

Lysine is a receptor antagonist of a specific serotonin receptor called 5 - HT4; it prevents serotonin (or 5 - HT) molecules from binding to and stimulating the receptor.

Conducted MTS and HTS functional screens (mGLUR2, mGLUR4, mGLUR5 and mGLUR7) and performed Dissociation and Association Kinetic Assay using FLIPR calcium mobility assay on cells transfected with metabotropic glutamate receptor.