Sentences with phrase «htt gene»

Humans have two copies of the HTT gene, HD happens when a mutation makes one copy too big.

WAVE designed ASOs that target two SNPs in the HTT gene, which is why they're launching two separate clinical trials.

Unfortunately, that means that about one third of people have the same ribbons at these points on both the good and bad kites, so these drugs wouldn't specifically target the mutant HTT gene.

These SNPs were chosen because their sequences tend to be different in the normal and mutant HTT gene: the ribbons at that point in the good and bad kites» tails tend to be a different colour, distinguishable by the drone.

They developed a way to switch off Cas once it's finished editing the HTT gene, thereby reducing the chances of it triggering an immune reaction or cutting somewhere it shouldn't.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

For example, scientists have not been able to resolve what function the HTT gene serves normally, or how its mutation creates problems in the brain.

HD is caused by a mutation in the human HTT gene that results in an abnormal expansion and misfolding of the corresponding huntingtin protein.

Next up: a larger trial in hundreds of patients to see if lowering mutant Htt protein slows progression of the disease, then a trial in healthy people who carry the mutant HTT gene to see if antisense treatments could prevent Huntington's altogether.

They used the gene editing technology CRISPR to engineer a series of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes.

Not exact matches

Each case can be traced to a bunch of repeated code letters of DNA within a single gene called HTT.

Mutations of the huntingtin protein (HTT) gene underlie both adult - onset and juvenile forms of Huntington's disease (HD).

They zeroed in on the serotonin transporter gene (HTT), which codes for a protein that re-absorbs serotonin into the nerve cell after it has been released.

It was initially called ISIS - 443139, but lately it's been going by IONIS - HTTRx or just HTTRx — a combination of HTT, the abbreviation scientists use for the huntingtin gene, and Rx, a symbol used in the pharmaceutical industry meaning a treatment or prescription.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from an extended number of CAG repeats in the Huntingtin (Htt) gene, for which no disease - modifying therapy is currently available, and comprises several cognitive and affective symptoms, as well as uncontrolled movement (chorea).

Association analysis of the catechol - o - methyltransferase (COMT), serotonin transporter (5 - HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive - compulsive disorder

The serotonin transporter gene (SLC6A4) contains a polymorphic region, known as 5 - HTTLPR, comprising a short (S) allele and a long (L) allele version that results in differential 5 - HTT expression and function (Lesch et al. 1996; Hariri 2009).

Adults who had been categorized as behaviorally inhibited at the age of 2 years exhibited a higher amygdala activation in response to unknown vs familiar faces16 compared with adults who were uninhibited as children, consistent with the notion that novel or ambiguous environmental stimuli of potential biological relevance activate the amygdala.17 Turning to genes that can influence the neurobiological bases of the processing of emotions, 2 common alleles, the short (S) and the long (L), in a variable repeat sequence of the serotonin transporter (5 - HTT) promoter polymorphism (5 - HTTLPR) on human chromosome 17q11 have been differently associated with greater amygdala activity in response to angry or fearful faces18 in healthy adults.

In addition to cultural factors, human behaviour is influenced by specific genes, such as the serotonin transporter gene (SLC6A4), which regulates serotonergic neurotransmission (5 - HTT)(Lesch et al. 1996; Canli & Lesch 2007).

Stressful life events and the serotonin transporter gene (5 - HTT) in recurrent clinical depression.

Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5 - HTT) in recurrent depressive disorder.

Early adversity and 5 - HTT / BDNF genes: New evidence of gene — environment interactions on depressive symptoms in a general population