Sentences with phrase «htt mrna»

Individuals carrying the S allele of the 5 - HTTLPR produce significantly less 5 - HTT mRNA and protein, resulting in higher concentrations of serotonin in the synaptic cleft relative to individuals carrying the L allele (Lesch et al. 1996).

Molecular studies at PsychoGenics and other organizations have demonstrated that the excision of the neomycin resistance cassette results in a modest but significant increase in mutant HTT mRNA levels, and a trend towards an increase in soluble mHTT protein and extranuclear inclusions.