And clearly we still have not fully grasped the issues at hand, as in 2013 researchers sequenced
the HeLa cell genome — and published it.
Any researcher wanting to use
the HeLa cell genome in their research has to request the data from this committee, and explain their research plans, and any potential commercialisation.
Her family will also be acknowledged in articles or talks resulting from the use of
HeLa cell genome data.
«Access to
HeLa cell genome data restored following agreement.»
Not exact matches
Lacks» family was never asked for permission to harvest her
cells, an ethical violation made worse in March when German researchers published the sequence of the
HeLa genome without asking.
Derived mostly from human embryonic kidney 293T (HEK293T) and
HeLa cell lines, EdiGene Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the target g
cell lines, EdiGene Knockout (KO)
Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the target g
Cell Lysates have been optimized through the use of
genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the target gene.
The first study to sequence and analyze the entire
genome of a
HeLa cell line, along with access to its sequence data, has been published Aug. 7 in its final version, by G3: Genes
Genomes Genetics, an open - access, scientific journal of the Genetics Society of America.
The new controlled access policy for full
genome sequence data from
HeLa cells will give the Lacks family the ability to have a role in work being done with the
HeLa genome sequences and track any resulting discoveries.
Under the policy, biomedical researchers who agree to abide by terms set forth in the
HeLa Genome Data Use Agreement will be able to apply to NIH for access to the full genome sequence data from HeLa
Genome Data Use Agreement will be able to apply to NIH for access to the full
genome sequence data from HeLa
genome sequence data from
HeLa cells.
Dr. Steinmetz and his team found the
genome of the
HeLa cell line that they sequenced differs dramatically from a normal human
genome sequence.
Access to the whole
genome data of these
cells will be a valuable reference tool for researchers using
HeLa cells in their research.
Earlier this year, researchers in Germany published a scientific paper that described the first sequence of the full
HeLa genome, comparing the DNA of
HeLa cell lines with that of
cells from healthy human tissues.
That paper, which acknowledges the contributions of the Lacks family, pieced together the complex, rearranged
genome of the
HeLa cells and identified an insertion of the human papilloma virus near an oncogene that may explain the aggressiveness of Lacks» cancer.
«Understanding the unique nature of the
HeLa genome is important for guiding future studies with these
cells,» explained Brenda Andrews, Ph.D., editor - in - chief of G3.
In addition, NIH - funded researchers who generate full
genome sequence data from
HeLa cells will be expected to deposit their data into a single database for future sharing through this process.
Genomics studies like those commonly conducted with
HeLa cells play an instrumental role in revealing how variation in
genome sequence and function can lead to disease.
Yet, «these studies using
HeLa cells had to rely on information from the «reference» sequence produced by the Human
Genome Project, even though there was evidence that the
genomes of
HeLa cell lines were probably quite different,» said Lars Steinmetz, Ph.D., who led the G3 study.
The National Institutes of Health today announced in Nature that it has reached an understanding with the family of the late Henrietta Lacks to allow biomedical researchers controlled access to the whole
genome data of
cells derived from her tumor, commonly known as
HeLa cells.
Given the widespread use of the
HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its
genome could illustrate the changes caused by cancer — and also help researchers compare versions of the
cell line that have evolved over decades of growth in labs around the world.
When European researchers published the
genome of the
HeLa cancer
cell line last month, they didn't think to ask for permission from the family of Henrietta Lacks, the woman those
cells came from — what some experts say was a serious ethical lapse.
«We apologized for any distress experienced by the family as a result of our recent publication of the
genome sequence of a
HeLa cell line.
The main argument in defence of publishing the
HeLa genome was that the
cell line was too different from the original
cells to provide any information on Henrietta Lack's living relatives.