Inclusion
Criteria: • Pathologically proven acute myeloid leukemia (AML) or intermediate, high - risk, or very high risk Myelodysplastic Syndrome (MDS) as defined by the World Health Organization (WHO) criteria or Revised International Prognostic Scoring System (IPSS - R) which is relapsed or refractory (R / R) to standard therapy and / or for which standard therapy is contraindicated or which has not adequately responded to standard
Criteria: • Pathologically proven acute myeloid leukemia (AML) or intermediate, high - risk, or very high risk Myelodysplastic Syndrome (MDS) as defined by the World
Health Organization (WHO)
criteria or Revised International Prognostic Scoring System (IPSS - R) which is relapsed or refractory (R / R) to standard therapy and / or for which standard therapy is contraindicated or which has not adequately responded to standard
criteria or Revised International Prognostic
Scoring System (IPSS - R) which is relapsed or refractory (R / R) to standard therapy and / or for which standard therapy is contraindicated or which has not adequately responded to standard therapy.
Data on maternal mental
health was also collected on the 36 - and 60 - month in - home assessments using the Composite International Diagnostic Interview Short Form (CIDI - SF) scale.44, 45 The CIDI - SF questions were
scored consistent with the developer's guidelines, which follow the
criteria of the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition).46 The CIDI - SF is based on a portion of the full CIDI and estimates the probability of being a case; if the respondent's
score is greater than 0.5, the respondent is classified as a probable case.
Many of the scales demonstrated weak psychometrics in at least one of the following ways: (a) lack of psychometric data [i.e., reliability and / or validity; e.g., HFQ, MASC, PBS, Social Adjustment Scale - Self - Report (SAS - SR) and all perceived self - esteem and self - concept scales], (b) items that fall on more than one subscale (e.g., CBCL - 1991 version), (c) low alpha coefficients (e.g., below.60) for some subscales, which calls into question the utility of using these subscales in research and clinical work (e.g., HFQ, MMPI - A, CBCL - 1991 version, BASC, PSPCSAYC), (d) high correlations between subscales (e.g., PANAS - C), (e) lack of clarity regarding clinically - relevant cut - off
scores, yielding high false positive and false negative rates (e.g., CES - D, CDI) and an inability to distinguish between minor (i.e., subclinical) and major (i.e., clinical) «cases» of a disorder (e.g., depression; CDI, BDI), (f) lack of correspondence between items and DSM
criteria (e.g., CBCL - 1991 version, CDI, BDI, CES - D, (g) a factor structure that lacks clarity across studies (e.g., PSPCSAYC, CASI; although the factor structure is often difficult to assess in studies of pediatric populations, given the small sample sizes), (h) low inter-rater reliability for interview and observational methods (e.g., CGAS), (i) low correlations between respondents such as child, parent, teacher [e.g., BASC, PSPCSAYC, CSI, FSSC - R, SCARED, Connors Ratings Scales - Revised (CRS - R)-RSB-, (j) the inclusion of somatic or physical symptom items on mental
health subscales (e.g., CBCL), which is a problem when conducting studies of children with pediatric physical conditions because physical symptoms may be a feature of the condition rather than an indicator of a mental
health problem, (k) high correlations with measures of social desirability, which is particularly problematic for the self - related rating scales and for child - report scales more generally, and (l) content validity problems (e.g., the RCMAS is a measure of anxiety, but contains items that tap mood, attention, peer interactions, and impulsivity).
Mothers with an infant aged up to 12 months were recruited at eight mental
health centers in The Netherlands, if they met the following inclusion
criteria: (a) having a diagnosis of a major depressive episode or dysthymia according to the DSM - IV
criteria [52](95 %) and / or
scoring above 14 on the Beck Depression Inventory [53] indicating increased levels of depressive symptoms (5 %); (b) having adequate fluency in Dutch; and (c) receiving professional outpatient treatment for their depression.