The reason pet parents want to feed their pets a diet high in fat is due to the way tumor cells, unlike
healthy cells use fat.
Healthy cells use most of their glucose «fuel» to produce energy, rather than for building components of new cells, such as fats and DNA.
For example, cancer cells tend to use glycolysis in the cell cytoplasm in their metabolism, an ancient system, whereas
healthy cells use oxidation - phosphorylation.
Not exact matches
Human Longevity has already received $ 70 million in private backing and aims to
use both genomics and stem
cell therapies to allow us to live longer,
healthier lives.
They include going after the damage to
cells done by free radicals, making
use of hormone therapy, or caloric restrictions, or vitamin supplements, or, most dramatically,
healthy gene selection through pre-implantation genetic diagnosis and even repairing the entire human genome.
If the egg is fertilized by a sperm
cell, it stays in the uterus and grows into a baby,
using that extra blood and tissue to keep it
healthy and protected as it's developing.
On Thursday, the United Nations» member states will consider two resolutions: One resolution would ban all human cloning methods, including efforts to
use cloned embryonic stem
cells to try and generate
healthy tissues, or to treat degenerative diseases such as Parkinson's.
In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging
healthy cells) and which is often
used as a model for autoimmune disease in general.
Because they can differentiate into almost any
cell type in the body, stem
cells have the potential to be
used to create
healthy cells to treat a number of diseases.
To do their job, T
cells use specialized receptors to differentiate
healthy cells from cancer
cells.
To make the rat kidneys, Ott and his colleagues took kidneys from
healthy «donor» rats and
used a chemical solution to wash away the native
cells, leaving behind the organ's scaffold.
«We concluded that stem
cells used in cardiac therapy should be drawn from
healthy donors or be better genetically engineered for the patient.»
In addition to
using healthy cells to do their work for them, cancer
cells also slowly destroy the skin's immune defence mechanism.
Only stem
cells from
healthy donors or genetically engineered
cells should be
used in treating cardiac conditions.»
Whether building organs or maintaining
healthy adult tissues,
cells use biochemical and mechanical cues from their environment to make important decisions, such as becoming a neuron, a skin
cell or a heart
cell.
One example of this research is the practice of
using stem
cells taken from a
healthy eye's limbus, the area around the cornea where stem
cells are stored, to create a layer of
healthy cells to replace damaged ones in the cornea, the transparent, dome - shaped layer of
cells covering the front of the eye.
Developed by Amgen, it
uses a modified version of the herpes virus that can't infect
healthy tissue but attacks cancer
cells.
The scientists in London got the same result in a similar experiment
using mammalian kidney
cells, showing that
healthy and mutant
cells compete directly against each other in mammals.
When they administered minocycline — a tetracycline antibiotic with anti-inflammatory properties commonly
used to treat bacterial infections, acne and arthritis — many of the abnormalities in the astroglial
cells were corrected and there were more
healthy interactions between the astroglia and neurons compared to the control
cells without the defect.
Another key finding of the research was that the impact of vitamin D on inflammatory disease can not be predicted
using cells from
healthy individuals or even from the blood of patients with inflammation as
cells from the disease tissue are very different.
Image courtesy of iStockphoto / BakiBG SAN ANTONIO, Texas — So much of our information from — and interaction with — the world is now mediated by computers,
cell phones and tablets that health experts have been practically running themselves ragged trying to find ways to
use these conduits to help people make
healthier choices.Great success stories have come out of parts of the developing world, where
cell phones have been
used to improve maternal and infant care and help people adhere to medication guidelines.
USE it or lose it: a class of immune
cell demolishes idle circuits and connections in the brain, even a
healthy one.
Interphone compared surveyed
cell phone
use in 6,420 people with brain tumors to that of 7,658
healthy people in 13 developed countries — Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden and the U.K. — to try to determine whether people with brain tumors had
used their
cell phones more than
healthy people, an association that might suggest that
cell phones caused the tumors.
The researchers then
used a 3 - D
cell culture system to coax their mutant and
healthy hPSCs down the differentiation pathway into becoming kidney progenitor
cells and finally the proximal tubule
cells found in kidney nephrons.
Stem
cell models, derived from
healthy or diseased
cells, are also being developed for
use in drug efficacy and toxicity testing.
Using tumor samples from the Women's
Healthy Eating and Living clinical trial, researchers identified stem - like tumor
cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).
His team plans to introduce a
healthy copy of the CF gene into
cells lining the nose and lungs,
using a lipid suspension that fuses with the
cell membrane and allows the gene to enter the
cell.
In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant
cells with toxic chemicals or radiation, which kills surrounding
healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are
using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.
Normal
healthy cells readily adapt to
using ketone bodies for fuel, but most cancer
cells lack this metabolic flexibility.
* No sperm necessary: By combining genetically altered
cells, Japanese scientists create a
healthy baby mouse
using only female DNA.
For the CRISPR trial, a UPenn - led team wants to remove T
cells from patients and
use a harmless virus to give the
cells a receptor for NY - ESO - 1, a protein that is often present on certain tumors but not on most
healthy cells.
«By identifying the full set of genes in each of these two
cell types, we provide detailed information that taste scientists can
use to help understand how these
cells work, both when
healthy and also when affected by damage or disease.»
In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists
used stem
cell technology to make large amounts of endothelial
cells from patients with CAVD, comparing them to
healthy cells and mapping their genetic and epigenetic changes as they developed into valve
cells.
Scientists already know how to
use a weakened strain of a respiratory virus called adenovirus to transport
healthy genes to
cells.
The research team first
used the blood of
healthy individuals, spiking some of the blood with living breast cancer
cells to see if the NanoFlares could detect them.
Targeted Alpha Therapy of prostate cancer
uses PSMA - 617, an anti-PSMA (Prostate Specific Membrane Antigen) peptide that specifically binds to prostate cancer
cells, but not to normal,
healthy cells.
The stem
cells used to treat Paizley, specific to the blood, came from the bone marrow of a
healthy adult donor.
Exploiting that power, researchers are now
using microRNAs to convert the scar tissue of damaged hearts into
healthy muscle
cells, opening the door for a better therapy after heart attacks and heart failure.
In May 2006, Eggan's lab received approval from Harvard to seek
healthy human eggs from female donors, a first step toward
using research cloning to create new stem
cell lines.
HSCT is effectively
used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing
healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.
Then De Luca and colleagues
used a retrovirus to insert a
healthy copy of the LAMB3 gene into DNA in the lab - grown skin stem
cells.
These individual transcriptomes can be
used to define
cell types and to understand the functions of
healthy and diseased
cells in the human body.
In previous studies, pulsating magnetic fields have been
used to deliver drugs, but the heat caused by the application can destroy
healthy cells of patients.
Previous research conducted by Dr. Badylak's team suggested that ECM also could be
used to regenerate lost muscle by placing the material in the injury site where it signals the body to recruit stem and other progenitor
cells to rebuild
healthy tissue.
The experimental treatment also spared
healthy cells, in these and in prior experiments, making the method potentially much less taxing on patients than commonly
used chemotherapy.
Lead author Nora Volkow, a psychiatrist at the National Institute on Drug Abuse of the National Institutes of Health, recruited 47
healthy volunteers and
used positron emission tomography (PET) scans to measure glucose metabolism in the brain while
cell phones were placed over the right or left ear.
The new approach builds on information gleaned from developmental studies of embryonic stem
cells (see story # 16) and one day may be
used to create
healthy replacements for harmed or diseased tissue.
Now, Salk Institute scientists have created a new tool that targets not DNA, but RNA, and
used it to correct a protein imbalance in
cells from a dementia patient, restoring them to
healthy levels.
In this project, the researchers
used single
cell technology to explore gene expression patterns in
healthy and diseased hearts.
HEALTHY DICHTY
CELL: A plump, well - nourished Dictyostelium discoideum cell uses ruffles in its membrane to bring in extracellular fluid, which contains chemical information about its environm
CELL: A plump, well - nourished Dictyostelium discoideum
cell uses ruffles in its membrane to bring in extracellular fluid, which contains chemical information about its environm
cell uses ruffles in its membrane to bring in extracellular fluid, which contains chemical information about its environment.