Sentences with phrase «high androgens affect»

Not exact matches

Women with PCOS tend to have high levels of insulin and androgens (like testosterone), causing symptoms that affect their overall health, fertility, appearance, and metabolism.

While DCI has been shown to improve insulin and androgens in PCOS, Isabella et al in 2012 showed that DCI alone, administered at high dosages (600-2400 mg daily) has been found to negatively affect oocyte quality and ovarian response.

While excess body weight is a main contributing factor to sleep apnea, high levels of androgens (male hormones such as testosterone) seen in PCOS, are believed to play a role in affecting sleep receptors.

Furthermore, high blood levels of insulin can act by increasing androgenous hormonal stimulation of the ovarian theca cells as well as potentiating gonadotropin - stimulated ovarian androgen steroidogenesis — although recent data has suggested that the insulin - induced increase in ovarian hormone secretion is not accompanied by increased steroid metabolism.74 Hyperinsulinaemia may also affect the central actions of androgen by impairing progesterone inhibition of the gonadotropin - releasing hormone pulse generator.75 Insulin has also been shown to increase expression of adrenal steroidogenic enzyme mRNA47 as well as adrenal responsiveness to adrenocorticotropic hormone.76

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as: