Sentences with phrase «high mutation burden»
High mutation burden correlates with defective SC function.
https://www.fightaging.org/ Not exact matches
Mutational signatures reveal high burdens of aristolochic acid — related mutations in Asian liver cancers, with Taiwan most intensely affected.
«The good news is that we discovered that a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.
Patients with both high tumor mutation burden and high PDL - 1 positive status had a 75 percent response rate compared with a 16 percent response rate to immunotherapy among patients with low mutation burden and low PDL - 1.
The combination of rapid but error - prone repair, the authors suggest, leads basal cells to accumulate a high burden of mutations that ultimately leads to carcinoma.
«The burden of mutations observed is high but almost certainly none of these clones would have developed into skin cancer,» explains Dr Iñigo Martincorena, first author from the Sanger Institute.
Its characteristically low mutational burden, high copy number and structural variants, and unique driver mutation prevalence are important in helping us understand the natural history of the disease and its response to various therapies.
A total of 244 abnormalities were identified in 79 genes in MCT - associated SCC, and the overall mutational burden was high (mean 10.2 mutations per megabase).
Conclusions: Ovarian SCC arising in MCT has a high mutational burden with TP53 mutation the most common abnormality.