Sentences with phrase «his2 zinc finger proteins»

His research interests include the roles of zinc in proteins including zinc finger proteins, the mechanisms and systems biology of protein targeting to peroxisomes, and the development of detailed thermodynamic understanding of molecular recognition processes.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters).

The zinc finger protein sticks to the DNA of the mutant Huntingtin gene and turns off the gene's expression.

The zinc finger protein works by targeting the mutant copies of the Huntingtin gene, repressing its ability to express and create harmful proteins.

For DNA cleavage to occur, two zinc finger proteins must bind, each to specific, adjoining sequences in the CCR5 gene, leading to FokI dimerization and subsequent DNA cleavage resulting in a double strand break [24]--[26].

(A) A CXCR4 - specific ZFN pair was generated, comprised of two DNA - binding zinc finger proteins (ZFPs) each fused with a FokI endonuclease monomer.

We identified the protein Organelle Zinc Finger Protein 1 (OZ1) as required for editing of 14 targets in Arabidopsis.

Even if given as an injection into the blood, the zinc finger protein would not reach the brain, let alone get as far as the nucleus of our neurons, where it needs to be in order to do its work.

When zinc hooks up with a gene - controlling protein, it forms «zinc finger proteins» - so called because they can poke into the tight groove between the two strands of DNA and touch the sequence they're made for.

My research has been about PR Domain Containing 9 (PRDM9), a multiple zinc finger protein that mediates the process of meiotic homologous recombination.

There were just four somatic mutations: two in known cancer genes and two in zinc finger proteins (these remain unexplained).

Global analysis of Drosophila Cys2 - His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants.

Not exact matches

However, in the presentations, speakers for both teams said that two stretches of the gene code for so - called zinc fingers — protein structures that insert themselves into the grooves of DNA — suggesting that the encoded protein probably turns other genes on and off.

Talk of curing AIDS made front - page news last year, in part due to an astonishing new gene - editing technology: lab - engineered proteins called zinc finger nucleases.

Its competitors — designer proteins called zinc finger nucleases and TALENs — also precisely alter chosen DNA sequences, and several companies are already exploiting them for therapeutic purposes in clinical trials.

These gene - regulating proteins have an important feature called a zinc finger domain.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cells.

The fusion protein bound optimally to a sequence containing adjacent homeodomain (TAATTA) and zinc finger (NGGGNG) subsites.

Last year, researchers targeted and destroyed this gene in the T - cells of 12 people with HIV using custom - made proteins called zinc finger nucleases.

To genetically disrupt the CXCR4 allele, we designed a pair of zinc - finger proteins (ZFPs) targeting the region of the cxcr4 gene that encodes residues Asp 187 to Val 196 in the second extracellular loop (ECL2) of this seven - transmembrane domain receptor using methods previously described [29]--[32](Figure 1).

Being proteins, zinc finger drugs are big, complex and fragile.

A single zinc finger can tickle any three letters, depending on the arrangement of the zinc and protein bits that make it up.

Zinc fingers could pull gene therapy back from the brink — but only if more researchers can get their hands on the remarkable proteins.

A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly (A) tail length.

Poly (ADP - ribose)- binding zinc finger motifs in DNA repair / checkpoint proteins.

Working with proteins called zinc finger nucleases and TALENs, Zhang attempted to edit the genomes of mammalian cells with a view to engineering them.

Prior to Cas9 activators, similar tools were made using other DNA binding proteins such as zinc fingers (ZF) and TAL effectors (TALE).

Proteins of the BAZ (bromodomain adjacent zinc finger) family are characterized by a carboxy - terminal bromodomain adjacent to a PHD finger and a WACZ motif.

Abbreviations: ACVR2A, activin A receptor type IIA; BMP, bone morphogenetic protein; BMPR, BMP receptor, type II; CNS, Central nervous system; DA, dopaminergic; DMEM / F12, Dulbecco's modified Eagle's medium nutrient mixture F - 12; E, embryonic day; GDF, growth differentiation factor; GO, gene ontology; KEGG, Kyoto encylopedia of genes and genomes; MAPK, Mitogen - activated protein kinase; mDA, midbrain dopaminergic; PD, Parkinson's disease; RIPA, radioimmunoprecipitation assay; SN, Substantia nigra; TGF - β, transforming growth factor - β; TH, tyrosine hydroxylase; VM, ventral midbrain / mesencephalon; Zeb2, Zinc finger E-box-binding homoeobox 2

Ultimately this will include the expanding repertoire of advanced technologies such as clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR - associated protein 9 (Cas9), and zinc - finger nucleases (ZFNs)(46) along with the new clinical indications and markets that they address.

Zinc finger technology is one of the hottest areas now in everything from gene therapy for HIV to increasing crop yield, to therapeutic protein production, to the great hope for stem cell therapy.

Here we report eight subjects from six families with predicted loss of function variants in ZNF462, a zinc - finger protein of unknown function.

Swapping the DNA binding domain of another telomeric protein, TRF2, with the zinc finger domains of TZAP showed that the TZAP zinc finger domains were sufficient to localize TRF2 to telomeres.

If you're an investor who's heard of zinc - finger proteins and gene editing but you aren't sure what it all means, this can help answer your questions.