Sentences with phrase «how cellular gene»
How cellular gene regulatory networks (GRNs) respond to the morphogen, in a concentration - dependent manner, is a pivotal question in developmental biology.
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They found a mechanism explaining how, in the case of pathological cardiac hypertrophy, cardiomyocytes lose their adult cellular state and regress back towards their fetal form, switching on genes that were originally expressed as the heart develops in the embryo and usually permanently switched off after birth.
The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»
The answer to this daunting biological riddle is central to understanding how the three - dimensional organization of DNA in the nucleus influences our biology, from how our genome orchestrates our cellular activity to how genes are passed from parents to children.
With these tools, Verma is revealing how the aberrant expression of normal cellular genes can causes tumors.
She also founded the Kathryn W. Davis RNAi Research Center at Cold Spring Harbor to support the understanding of how this cellular machinery might be programmed to turn off genes that lead to cancer and other disorders.
Ohsumi and his students, postdocs, and collaborators have had an outsized influence on this field, not only in identifying the genes that underlie cellular recycling, but in revealing many of the molecular details of how these players function.
Armed with this knowledge, the researchers believe they can determine the cell types, cellular functions and genes that are affected by smoking, and how that varies between healthy and COPD - afflicted lungs.
She has pioneered the intergration of large - scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, providing insight to cellular mechanisms underlying genetic risk for disease.
«This is the only system I know about that is amenable for structural work on how the cellular signal comes down to the chromatin and DNA and that can provide an answer about how a signal activates a eukaryotic gene,» Panne says.
The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.
Dr. Loftus» research is aimed at understanding how the human genome regulates gene expression, with a focus on how this controls the cellular processes governing mammalian development.
Studies at the cellular level help us to understand how the gene products involved in learning and memory mediate physiological changes in the neurons that encode memories.
The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.
Manuscripts typical of this section would describe experiments generating and analyzing lists of genes and studies of how those genes combine to regulate: differentiation of a particular cell type; cellular, tissue, or organ response to toxic / pathogenic agents; adaptation to environmental stresses.
«Vertical integration of gene function» describes how gene expression initiates a series of biochemical, cellular, and physiological changes that ultimately culminate in an observable behavior.
The focus of the Mar lab is to understand how variability in gene expression contributes to the regulation of cellular phenotypes.
I recently read the book «Deep Nutrition: Why Your Genes Need Traditional Foods» and I found it to be a must - read health book that explains in a very detailed and easy - to - understand way how our diets affect us on a cellular level.
The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.
Our research and product development teams continue to conduct studies investigating new compounds, as well as determining how our current products affect our companions at the most basic cellular level, including gene expression.
Molecular medicine and molecular biochemistry provide the what and how these changes, especially deleterious ones may be treated, cured, suppressed, or understood in context with other gene regulatory mechanisms and transcription and translation coupled systems within the actual cellular environment.