Sentences with phrase «hox gene clusters»

Not exact matches

To demonstrate that CTCF binding is necessary for correct Hox gene activation, the researchers removed the sites on the genome where CTCF would normally bind and showed that without that CTCF binding, the Hox cluster would not fold properly.

Hox genes are arranged in several clusters, and their order and spacing within the clusters — which varies little between insects and humans — turns out to be central to the way they work.

In trying to understand the sequential activation of the Hox - D genes, Duboule has come up with the novel idea that the timing is linked to the arrangement of the genes within the clusters.

Denis Duboule and his colleagues at the European Molecular Biology Laboratory in Heidelberg, working with mice, showed that genes in the Hox - D cluster, which define the head - to - tail body axis, are activated one after another and at a precise time during development of the embryo.

The research team had previously identified a section of DNA adjacent to the HoxD gene cluster, which formed a particular 3D structure in order to interact with and activate certain Hox genes.

bilaterians: A clade of animals whode members share: bilateral symmetry, are triploblastic (three tissue layers: ectoderm, mesoderm, endoderm), and with HOX genes in one or more clusters with the genes within a cluster arranged in the same order as the body parts they affect.

Anecdotal data on an increasing number of genes support this view: Drosophila has one copy each of the Ras, Raf and Notch genes, as well as of the genes of the Hox cluster, while vertebrates have three or more of each of these genes.

Hox genes, for example, control body plan development and cluster together in almost all animals.