Sentences with phrase «human drug research»

«I know for a fact that the agency will lose half its collaborators when it moves,» says pharmacologist Adam Cohen, who heads the Centre for Human Drug Research in Leiden, the Netherlands.

Vahrmeijer and Jacobus Burggraaf, MD, PhD, from the Centre for Human Drug Research in the Netherlands, studied OTL38 for the first time in humans.

Adam Cohen, professor of clinical pharmacology and director of the Centre for Human Drug Research, surveys the situation for clinical researchers in the Netherlands.

Not exact matches

Animal Research: For nearly four decades, the animal liberation movement has been at war with medical research conducted on animals — even though conducting such experiments before trying new drugs or procedures on people is a crucial human rights protection established in the NurembeResearch: For nearly four decades, the animal liberation movement has been at war with medical research conducted on animals — even though conducting such experiments before trying new drugs or procedures on people is a crucial human rights protection established in the Nuremberesearch conducted on animals — even though conducting such experiments before trying new drugs or procedures on people is a crucial human rights protection established in the Nuremberg Code.

The Grocery Manufacturers Association (GMA) last week urged the Food and Drug Administration to ensure any proposed long - term sodium reduction targets are based on a review of the Dietary Reference Intake (DRI) for sodium, future knowledge gained from work on the short - term sodium reduction targets, results of new research that will become available on human health outcomes and dietary sodium intake, and the emergence of new technologies that allows sodium reduction targets to be safely and effectively achieved.

* U.S. Department of Health and Human Services, National Institute on Drug Abuse — Preventing Drug Use among Children and Adolescents — A Research Based Guide for Parents, Educators and Community Leaders, Second Edition

Using the latest research to rate the safety of each drug, the authors provide easy - to - understand explanations of how drugs enter human milk and possible side effects.

Dr. Perry's research includes: the effects of prenatal drug exposure on brain development, the neurobiology of human neuropsychiatric disorders, the neurophysiology of traumatic life events, and long - term cognitive, behavioral, emotional, social and physiological effects of neglect and trauma in children, adolescents and adults.

The research was funded by the Eunice Kennedy Shriver National Institute of Child Health & Human Development, the National Institute on Drug Abuse, and the National Institute of Mental Health.

Studies show that these models can accurately predict the ways that new drugs will react in the human body and replace the use of animals in exploratory research and many standard drug tests.

Randolph Nesse and Kent Berridge, psychiatric investigators with the Institute for Social Research at the University of Michigan in Ann Arbor, reported in Science that medicine may never win the war against drug addiction because «it is rooted in the fundamental design of the human nervous system.»

While some published steroids have a research trail, most psychoactive drugs have never been tested on humans — until, that is, they show up at clubs or parties.

His particular interest is learning how the parasites developed the ability to keep the blood of their victims flowing; his research could lead to new anti-clotting drugs for humans.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Building the knowledge base requires humans to teach computers key concepts from curated articles; with modest online training, anyone who reads English can scan research papers for key terms — names of genes, proteins, diseases, and drugs — and use online marking tools to document relationships between them (for example, drug X treats disease Y).

The U.S. Food and Drug Administration banned it from conducting human trials, and Wilson left his post at the now defunct institute (but he continued doing research at Penn).

«So far, the drug has only been tested in mice, and while some research in human genetics suggests this approach could work in people too, we need more research before we know how relevant this could be for people with type 2 diabetes.»

The Food and Drug Administration immediately terminated all gene therapy trials there, and the incident prompted federal regulators to establish new rules for human gene therapy research.

Preliminary results of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further research into the use of endectocide class drugs, of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight against malaria and other mosquito borne disease.

Clinical research focuses on interventional human trials to evaluate drugs and treatments in a controlled setting.

Pressure to ban the practice has fallen on the US Food and Drug Administration (FDA) following a court ruling and the publication of research showing how a strain of bacteria jumped from humans to farm animals and back again, picking up antibiotic resistance on the way.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

Attacked by critics who insisted it wasn't ethical to use the drug on young patients who weren't yet psychotic, McGlashan says he supplied «about 200 pounds» of supporting documentation to the federal Office for Human Research Protections before he got a green light to continue.

Some said they also kept tabs on officials involved in drug testing: 55 schools (70 percent) reported monitoring senior and mid-level officials responsible for hiring and firing, and 62 of them (81 percent) said they kept an eye on members of so - called institutional review boards, who approve human research proposals.

Because of the legislation, a FDA spokesperson noted in an email, «the agency will not receive or review INDs [Investigational New Drug applications] for human subject research utilizing genetic modification of embryos for the prevention of transmission of mitochondrial disease in FY 2016 and human subject research using these technologies can not be conducted in compliance with the Federal Food, Drug, and Cosmetic Act and FDA's implementing regulations.»

Therefore, the research shows that these mutations affecting the signalling route which depends on the ATM protein, as well as the drugs inhibiting the function of this signalling route such as some anti-tumour drugs, could produce infertility problems in humans.

«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of tResearch and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of tresearch program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

«Given the key similarities to human infections, a marmoset model of Zika may be useful for testing of new drug and vaccines,» said Texas Biomedical Research Institute virologist Jean Patterson, Ph.D. «Having an animal model of Zika infection to study may help us identify places where we might be able to block transmission.»

Novartis is one of many drug companies with new medicines being tested in humans, according to Pharmaceutical Research and Manufacturers of America.

As a next step, Dr. Reimer's research team intend to analyse the effect of different drugs on zebrafish OPCs in order to potentially identify a method to improve functional spinal cord repair in humans.

Yavin Shaham, a neurobiologist at the National Institute on Drug Abuse in Bethesda, Md., said in a press statement that the new work is an example of «basic research that can be readily translated to the treatment of cocaine addiction in humans.»

In research published in BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use today.

Department of Health and Human Services (DHHS)-- bridging the missions of NIH with AHRQ and the Food and Drug Administration (FDA) and integrating traditional NIH clinical research with health services, outcomes, and medical - effectiveness research.

Although human drug trials are several years away, Leinwand has cofounded a company to fund her research.

Among the areas determined to be flawed and in need of more research are: accuracy and error rates of forensic analyses, sources of potential bias and human error in interpretation by forensic experts, fingerprints, firearms examination, tool marks, bite marks, impressions (tires, footwear), bloodstain - pattern analysis, handwriting, hair, coatings (for example, paint), chemicals (including drugs), materials (including fibers), fluids, serology, and fire and explosive analysis.

Indeed, the authors note the speed with which a second FDA - approved drug believed to have promise in subduing HIV, Deferiprone, has moved directly from tests in culture to a phase I human trial conducted in South Africa, thanks to previously published results now reinforced by additional research in culture described in the current paper.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

In recent research published in the Journal of Biological Chemistry, Saint Louis University investigators report catching integrase, the part of retroviruses like HIV that is responsible for insertion of the viral DNA into human cell DNA, in the presence of a drug designed to thwart it.

Draper's human organ system should be able to identify effective drugs and ineffective ones early in the drug discovery process, allowing developers to refocus resources on the strong candidates earlier and end unproductive research earlier, minimizing costs, Borenstein said.

The next phase of research will involve testing in humans, which was approved last year by Health Canada and the U.S. Food and Drug Administration.

He added that the existence of episodic memory in lower animals has implications for research on human diseases that affect memory, including Alzheimer's, Parkinson's and Huntington's diseases, since the majority of research on the brain — and the drugs used to treat memory diseases and dementia — start out based on insights into how the brain works in rats.

«The ultimate goal of this research will be to advance HIF - 1alpha stabilizers toward clinical trials in humans, using versions of the drug that can be taken orally and reach the urinary tract,» Nizet said.

«If our findings are confirmed in human studies, the new drug regimens that we have identified should dramatically shorten the time needed to treat tuberculosis,» said Dr. Marcus Horwitz, a senior author on the research and a distinguished professor of medicine and microbiology, immunology and molecular genetics at the UCLA David Geffen School of Medicine.

«As these CaSR - modulating drugs already exist, even though their use is currently restricted to a few diseases, they have been tested and approved for human use,» explains project coordinator Enikö Kallay of the Department of Pathophysiology and Allergy Research at the Center of Pathophysiology, Infectiology and Immunology.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

In the first study of the drug lorcaserin in the human brain, the research revealed the mechanism underlying the drug's efficacy and provides insight into which individuals may benefit most from the medication.

«We were very excited to discover that when we used a typical genetic mutation that was more susceptible to electroconvulsive seizures, we were able to actually rescue these worms by treating them with FDA approved human antiepileptic drugs beforehand,» said Monica Risley, co-lead author and a Ph.D. student in FAU's Integrative Biology and Neuroscience program, as well as a student in the new International Max Planck Research School in Brain and Behavior.

«Importantly, we use mice as models of human beings in research, and so when looking for anti-obesity drugs, we need to fully understand the function of the NPY system in this animal model to understand how similar circuits in humans connect with the body clock.»

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

This has resulted in industry laboratories dedicated to drug discovery or human genome research.