Sentences with phrase «human protein atlas»

The previous iteration of Project Discovery yielded incredible results in a short amount of time, with players submitting over 25 million classifications of human cells back to the Human Protein Atlas.

I loved the idea of the Human Protein Atlas mini game in EVE but sadly my poor eyesight prevented me from fully taking part in it.

Autoantibody screening using planar protein arrays based on Human Protein Atlas protein fragments, with subsequent verification using suspension bead arrays in a larger patient sample material.

The Human Protein Atlas maps for the first time the human proteins in all major organs and tissues, showing both proteins restricted to certain tissues, such as the brain, heart, or liver, and those present in all.

Supported by the resource of more than 42 000 unique human protein fragments generated within the Human Protein Atlas, representing more than 18 000 human protein coding genes, we offer proteome wide screening for autoantibody reactivity, on the, as well as downstream solutions for investigation of autoimmunity in hundreds of patient samples in parallel.

She named two successful examples of multidisciplinary research taken from SciLifeLab: The Human Protein Atlas led by Mathias Uhlén and the work of Johan Elf and colleagues to use both quantitative physical models and biological observations to understand the key steps in transcription, translation and replication.

One of the projects entails enabling the Human Protein Atlas to improve and enhance its open access database and add integrate new technologies such as high multiplex imaging into the spatial data already in Human Protein Atlas.

Started in 2003, two years after the first draft of the human genome, it has taken a team of scientists and IT engineers over 1,000 man years to complete the Human Protein Atlas to yield an interactive database containing 13 million annotated images.

The Human Protein Atlas project, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using Antibody - Based Proteomics.

It comprises a collection of the human proteome represented by 42 000 unique protein fragments from the Human Protein Atlas resource, covering 19 000 protein coding genes.

A decade after the completion of the human genome, the Human Protein Atlas program today launched a tissue - based atlas covering the protein complement of the human genome.

In the findings it reported in May, the Human Protein Atlas began to demonstrate why these refinements may be necessary.

The protein atlas now also includes a Dictionary that aims to facilitate the interpretation and use of the image - based data available in the Human Protein Atlas, but also to serve as a tool for training and understanding tissue histology, pathology and cell biology.

The Human Protein Atlas contains images of histological sections from normal and cancer tissues obtained by immunohistochemistry.

Antibodies included in the Human Protein Atlas have been analyzed without further efforts to optimize the procedure and therefore it can not be excluded that certain observed binding properties are due to technical rather than biological reasons and that further optimization could result in a different outcome.

The Human Protein Atlas (HPA) program is a scientific research program with the goal to explore the entire human proteome.

A research article published in Science presents the first major analysis based on the Human Protein Atlas.

A histological dictionary used in the annotation is available as a PDF - document, containing images stained by immunohistochemistry using antibodies included in the Human Protein Atlas.

Therefore vesicle - like stainings are annotated as «vesicles» in the Human Protein Atlas and the terms «endosomes», «lysosomes» and «peroxisomes» are only used if colocalization experiments were carried out.

The Human Protein Atlas project, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using antibody - based proteomics.

«We are excited about the efforts to create a Human Cell Atlas and the addition of new emerging tools to create a knowledge - based platform for understanding the human cell» says Mathias Uhlen, Director of the international Human Protein Atlas consortium.

For more information on the Human Protein Atlas, visit our website at www.proteinatlas.org

The normalized Tags Per Million for each gene were calculated and subsequently used to categorize the genes using the same classification as described above and using Tags Per Million ≥ 1 as threshold for detection to allow for comparisons with the Human Protein Atlas data.

The article gives an overview on techniques that are used to locate proteins within cells and Emma Lundberg shares her experiences from her work with the Subcellular Protein Atlas within the Human Protein Atlas, HPA.

The tissue microarray method used within the human protein atlas enabled the global mapping of proteins in the human body, including the brain.

New data are released annually to the publically available information portal, the Human Protein Atlas.

The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells.

In his talk, Devin Sullivan, KTH Royal Institute of Technology, told the audience how it came to be that 200,000 gamers contributed to the Human Protein Atlas.

Professor Mathias Uhlen, Director of the Human Protein Atlas consortium and leader of the Pathology Atlas effort says: «This study differs from earlier cancer investigations, since it is not focused on the mutations in cancers, but the downstream effects of such mutations across all protein - coding genes.

The Pathology Atlas also contains 5 million pathology - based images generated by the Human Protein Atlas consortium.

Through collaborations with i.a. the SciLifeLab Biochemical and Cellular Screening facility, members of the Human Protein Atlas and teams supervised by Carolina Wählby (Uppsala University / SciLifeLab), Erik Sonnhammer (Stockholm University / SciLifeLab), and Pål Stenmark (Stockholm University), a comprehensive overview of the human NUDIX hydrolases has been produced.

The article, Tissue - based map of the human proteome, is one of 340 papers published by researchers in the Human Protein Atlas project, led by Mathias Uhlén at KTH Royal Institute of Technology / SciLifeLab.

The launch is accompanied with an article in Molecular Systems Biology describing transcriptome resources with a focus on the comparison between the datasets generated from the Broad Institute, Boston, US (GTEx) and the Human Protein Atlas consortium at SciLifeLab.

The work depends heavily on the supercomputing power available to the Human Protein Atlas consortium through the SciLifeLab (Science for Life Laboratory).

The study's network modeling approach relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia.

'' The inclusion of the GTEx dataset to the Human Protein Atlas database makes it even more comprehensive and it is reassuring that there is a significant overlap in the tissue classification of the genes based on the two independent datasets.»

The Human Protein Atlas is a multinational research project led by Mathias Uhlén, KTH Royal Institute of Technology / SciLifeLab.

«We are truly excited about the RNA transcript data and the map of gene expression that we now have for 27 different organ - specific tissues», says Professor Mathias Uhlén, Program Director of the Human Protein Atlas.

The Human Protein Atlas consortium has launched version 15 of the database including extensive transcriptomics data.

Today the Human Protein Atlas is releasing version 11.0 of the protein atlas (www.proteinatlas.org).

The Human Protein Atlas has reached a major milestone by releasing protein data for more than 80 % of the human protein - coding genes and RNA expression data for more than 90 % of the genes.

SciLifeLab hosting parts the Human Protein Atlas program will be collaborating with the ELIXIR coordinator EMBL - EBI in exploring possibilities to link the data held in the Human Protein Atlas with other data resources.

The project behind the Human Protein Atlas started as a small research project at KTH Royal Institute of Technology in the research group of Professor Mathias Uhlén in 2000.

The facility has access to an internal resource of > 35,000 antibodies from the Human Protein Atlas project.

A new chapter of the Human Protein Atlas, HPA, has been launched: The Cell Atlas — an open - access interactive database of images showing the location of over 12,000 proteins in cells.

The 12th release of the Human Protein Atlas (HPA) covers 16,621 genes (approximately 83 % of the human protein - coding genes) and includes protein expression profiles based on 21,984 antibodies.

They also mined public databases (GNCPro, TiGER, Human Protein Atlas) to identify molecular markers of the hindgut in the adult colon.

By comparing RNA sequencing with the Human Protein Atlas, we've also been able to identify new markers for the bile ducts that confirm the malformations that develop in patients with Alagille Syndrome.»

Uhlén's group has been systematically testing all the antibodies used for the Human Protein Atlas to see if they meet the new standards.

Dr. Lundberg is currently the director of the Cell Atlas, part of the Swedish Human Protein Atlas program, and an elected member of the executive committee of the Human Proteome Organization.