Human geneticists used this code to pinpoint variations that underlie human disease.
Not exact matches
Geneticist and writer Rutherford takes a sweeping new view of the
human evolution story,
using the latest science of DNA as the central guide.
Most of the rechristened genes were identified by
geneticists studying the fruit fly; when equivalent genes were later found in the
human genome, researchers simply continued
using the name of the fruit fly gene to avoid confusion.
The new study, led by Johannes Krause, a
geneticist at the Max Planck Institute for the Science of
Human History in Jena, Germany, used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled human
Human History in Jena, Germany,
used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled
humanhuman DNA.
The millions of base pairs of sequence that Genovese and McCarroll's team have located will be added to the next release of the reference
human genome assembly — the «Google maps» of the
human genome that
geneticists use every day — providing a more comprehensive view of the genome and how the pieces all fit together.
Co-author Andrea Manica, a population
geneticist at the University of Cambridge in the United Kingdom, has posted a note online explaining that incompatibility between two software packages
used to compare Mota's genome with the reference
human genome led the software program to simply drop certain DNA variants, with the result that all living Africans seemed to have inherited more «Eurasian» DNA than they actually did.
Because mitochondrial DNA is inherited only from the mother,
geneticists use it to trace how much it has changed over the years and identify branches in
human evolution and our spread around the globe.
«This is a very large scale study
using a new, innovative statistical method,» said study co-senior author Kenneth S. Kendler, M.D., professor of psychiatry, and
human and molecular genetics in the Virginia Commonwealth University School of Medicine, and an internationally recognized psychiatric
geneticist.
Geneticist Dana Carroll of the University of Utah in Salt Lake City, who was at the Napa meeting, says that it will call for discussions of the safety and ethics of
using editing techniques on
human embryos.
The study is «a beautiful example of the
use of isolated populations to study
human genetic disease,» observes
geneticist Val Sheffield of the University of Iowa in Iowa City, but he cautions that it's premature to talk about a cure for the disease.
Evolutionary
geneticists Svante Pääbo, Johannes Krause, and colleagues at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, ground up a 30 - milligram sample and extracted and sequenced all of the 16,569 base pairs of its mtDNA genome,
using new techniques Pääbo's group has successfully employed to sequence both Neandertal and prehistoric modern
human DNA.
The finished atlas, Mazziotta says, will serve a purpose similar to what the
Human Genome Project has done for
geneticists, providing a detailed framework of the brain that researchers can
use to perform experiments.
Such ease of
use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the worksho
use will likely encourage the
use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the worksho
use of more animal models in the study of
human diseases, says Rhonda Wiler, a
geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal
Use (which organized the worksho
Use (which organized the workshop).
In a series of studies this year, molecular
geneticists at the University of Pittsburgh School of Medicine
used a harmless virus to ferry new genes through the bloodstream, across blood vessel walls, and into almost every muscle cell in the bodies of hamsters bred to have
human genetic diseases.
Evan Eichler and Devin Locke,
geneticists at Case Western University in Cleveland, Ohio,
used a different type of array, fitted with much bigger pieces of
human genetic material, to study insertions and deletions of up to about 150,000 bases.
Geneticist Yoav Gilad of the University of Chicago and his colleagues
used a new technique to examine the genes in the liver cells of four primates:
humans, chimpanzees, orangutans and macaques.
Geneticist Manfred Kayser of the Erasmus University Medical Center in Rotterdam, the Netherlands, an author of the other paper that appears in The American Journal of
Human Genetics, says if police fully understood mutations behind eye color, for example, then they could
use them to determine the eye color of a suspect based solely on DNA evidence.
The mission of Interactive Biosoftware is to provide
geneticists and researchers with the most sophisticated software that is easy to
use and reliable to make appropriate diagnostics, surveillance, and information sharing between, and across, all tiers of
human genome research.
The most popular model
used by
geneticists for the last 35 years to detect the footprints of
human evolution may overlook more common subtle changes, a new international study finds.