Human gut microbiome Gut microbiome composition in lean patients with NASH is associated with liver damage independent from caloric intake: a prospective pilot study — Sebastião Mauro Bezerra Duarte — Nutrition, Metabolism and Cardiovascular Diseases
Not exact matches
The «
microbiome,» or the collection of organisms that reside within the
human body (especially the
gut), has become a big new interest area for a number of major pharma companies like Merck and smaller biotechs alike.
To find out what was going on in the
microbiomes of four sets of differently shaped identical twins, researchers transferred some
gut bacteria from a lean (
human) twin to a sterile mouse: one with no foreign bacteria at all.
The company is a pioneer in the
human microbiome, which is essentially the bacteria that inhabits the
gut and skin
There is growing interest in the role of the
gut microbiome and its effect on
human health.
Lactobacillus is a probiotic bacteria that is part of a healthy
human microbiome and aids in digestion and
gut health.
As it turns out,
human milk feeds both the baby AND the good bacteria in baby's
gut microbiome.
Previous studies have shown that a high fat maternal diet during gestation and lactation has a long - term impact on the infant's
gut microbiome (the community of bacteria living inside the
human gut.)
Some studies have also linked the
microbiome to
human mood and behavior as well as
gut health,
human development, and metabolic disorders.
In a study to be presented Thursday, Jan. 26, in the oral plenary session at 1:15 p.m. PST, at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, researchers with Baylor College of Medicine, Houston, Texas and University of California, San Diego, La Jolla, California, will present their findings on a study titled, Maternal Diet Structures the Breast Milk
Microbiome in Association with
Human Milk Oligosaccharides and
Gut - Associated Bacteria.
Few biological mechanisms may explain the inverse relationship between breastfeeding and leukemia including more favorable
microbiome in an infant's
gut and natural - killer and stem cells in
human milk.
Among
human archaeological remains, coprolites can be a uniquely valuable record of ancient
gut microbiomes — but they're rare to find.
Our cover story, «The Ultimate Social Network,» by Jennifer Ackerman, describes the efforts to map our
human microbiome — no easy feat when certain critters, such as the
gut bacteria that prosper in an oxygen - free environment, are challenging to grow in petri dishes in a laboratory.
Dr Luis Pedro Coelho, corresponding author of the study, commented: «We found many similarities between the gene content of the
human and dog
gut microbiomes.
«Cultural revolution in the study of the
gut microbiome:
Human gut - on - a-chip technology used to co-culture gut microbiome, human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
Human gut - on - a-chip technology used to co-culture
gut microbiome,
human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
human intestinal cells could lead to new therapies for inflammatory bowel diseases.»
The Wyss team believes the ability of the
human gut - on - a-chip to culture the
microbiome with
human gut cells also holds promise for the field of precision medicine, where a patient's own cells and
gut microbiota could one day be cultured inside a
gut - on - a-chip for testing different therapies and identifying an individualized treatment strategy.
Although the mouse
gut microbiome presents a number of similarities with the
human microbiome, the work showed that around 20 percent of the strains in the collection prefer colonizing the intestines of mice.
With our
human gut - on - a-chip, we can not only culture the normal
gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
In this latest advance reported in PNAS, the Wyss team showed that the
human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal
gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to
human health and disease.
«The distal
gut of a
human is one of the densest microbial ecosystems on the planet,» says Stanford University microbiologist David Relman, a pioneer in
human microbiome research.
In the last four years, the U.S. - based
Human Microbiome Project used genomic analysis to identify bacteria, viruses, fungi, archaea, and protozoa in the noses, gums, tonsils, genital tracts, and
guts of 242 healthy Americans between the ages of 18 and 40; more than 11,000 samples were taken in all.
As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as
humans point to the link between the
gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the
gut microbiome.»
Just how does HIV infection affect the
human gut microbiome?
«Because Candida is a natural component of the
human body
microbiome, yeast overgrowth or infection in the digestive tract, for example, may disrupt the
gut - brain axis.
That's the tantalizing finding from a new study published today that reveals a way that mice — and potentially
humans — can control the makeup and behavior of their
gut microbiome.
For example, when they tested the
gut microbiome from a healthy
human male the old way, they found 127 different species.
In 2008, when he fed Lactobacillus to mice with a transplanted
human microbiome, he observed metabolic changes in the animals»
gut, liver, kidneys, and parts of the brain.
Like a lush rain forest, a healthy
microbiome in the
human gut is a diverse ecosystem that thrives only when all the interdependent species are healthy too.
The U.S. - based
Human Microbiome Project used genomic analysis to I.D. microbes in the noses, gums, tonsils, genital tracts and
guts of more than 200 Americans.
«Our new findings suggest that black tea, through a specific mechanism through the
gut microbiome, may also contribute to good health and weight loss in
humans.»
By chemically removing the
gut microbiome in zebrafish in the lab and then repopulating the
gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications for
human health.
Human milk's most important role could be preventing infant disease and boosting immunity by cultivating a balance of microbes in the
gut and the rest of the body, a kind of internal ecosystem called the
microbiome.
To investigate, researchers from the Channing Division of Network Medicine at Brigham and Women's Hospital, led by Amir Bashan, PhD, and Yang - Yu Liu, PhD, analyzed data from large metagenomic datasets (e.g. the
Human Microbiome Project and Student
Microbiome Project) to look at the dynamics of the
gut, mouth and skin
microbiomes of healthy subjects.
«Every
human carries trillions of bacteria in their
gut (
gut microbiome) and recent advances in research indicate that these tiny passengers play an important role in our overall health maintenance,» says Ashutosh Mangalam, PhD, assistant professor of pathology at the University of Iowa Carver College of Medicine.
Food not metabolized directly by a host like a mouse or a
human is subsequently processed in the
gut by the bacteria of the
microbiome.
We identify ocean microbial core functionality and reveal that > 73 % of its abundance is shared with the
human gut microbiome despite the physicochemical differences between these two ecosystems.
ET: «What this data analysis pipeline, moreover, creates is motivation to look for similar forms of gene loss in other types of symbioses, such as that between
humans and their
gut microbiomes.
(
Gut bacteria are part of the
microbiome, the larger community of microbes that exist in and on the
human body.)
Rather, it conveys the subtle and elegant choreography of one part of the
human microbiome: The relationships between the mothers» genetics, the composition of her breast milk and the development of her infant's
gut microbiota.
«
Human gut microbiome evolution: From hunter - gatherers to a western lifestyle.»
The research examining the differences in infant
gut microbial populations arising from differences in human milk oligosaccharides (sugars), «Maternal Fucosyltransferase 2 Status Affects the Gut Bifidobacterial Communities of Breastfed Infants,» is published online today in the journal Microbiome, a BioMedCentral journ
gut microbial populations arising from differences in
human milk oligosaccharides (sugars), «Maternal Fucosyltransferase 2 Status Affects the
Gut Bifidobacterial Communities of Breastfed Infants,» is published online today in the journal Microbiome, a BioMedCentral journ
Gut Bifidobacterial Communities of Breastfed Infants,» is published online today in the journal
Microbiome, a BioMedCentral journal.
The lack of fiber in modern Western diets is often thought to cause harmful perturbations to the
human gut microbiome.
Large - scale genome sequencing efforts, like the
Human Microbiome Project, have focused on the community of microorganisms that live in the human
Human Microbiome Project, have focused on the community of microorganisms that live in the
humanhuman gut.
Since the
human body plays host to vast numbers of bacteria, particularly our
gut microbiome, this effectively means that there is a bacterial war going on inside us.
Howard Ochman of the University of Austin in Texas and his team sequenced the
gut microbiomes of hundreds of wild chimpanzees, bonobos and gorillas, and those of hundreds of
humans living in US cities and in Venezuela and Malawi.
In recent years, the study of
human biology has been shaken up by discoveries of how the bacteria that live in the
gut, the so - called
microbiome, affect metabolism, the immune system, and disease progression.
The whipworm lives in the
human gut, mooching microbes from its host to build its own
microbiome.
«We set out to find out about
human genes that are implicated in the regulation of the
gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the study's senior author.
«In the future, such efforts could allow us to much better understand
human -
microbiome interactions, model malnutrition disorders and inflammatory diseases of the
gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's team.
(American
Gut is a crowd - sourced project aimed at characterizing the
human microbiome by the Rob Knight Lab at the University of California San Diego.)